A super hydrophilic silsesquioxane-based composite for highly selective adsorption of glycoproteins

The authors have prepared a super-hydrophilic polymer consisting of a poly-polyhedral oligomeric silsesquioxane (POSS)-formaldehyde (PPF) composite. The polymerization process does not require a catalyst and results in a material with excellent hydrophilic properties and abundant functional groups....

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2017-04, Vol.184 (4), p.1037-1044
Main Authors: Zhang, Yue, Zhuang, Yuting, Shen, Huiyan, Chen, Xuwei, Wang, Jianhua
Format: Article
Language:English
Subjects:
Adsorption
Analytical Chemistry
Biological properties
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Formaldehyde
Functional groups
Glycoproteins
Hydrophilicity
Microengineering
Nanochemistry
Nanotechnology
Original Paper
Ovalbumin
Polyhedral oligomeric silsesquioxane
Polymerization
Proteins
Selective adsorption
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Summary:The authors have prepared a super-hydrophilic polymer consisting of a poly-polyhedral oligomeric silsesquioxane (POSS)-formaldehyde (PPF) composite. The polymerization process does not require a catalyst and results in a material with excellent hydrophilic properties and abundant functional groups. The PFF composite, even if not chemically modified, can selectively bind glycoproteins due to strong hydrophilic interactions. It is shown that glycoproteins can be selectively captured by the composite that has a binding capacity as large as 542 mg g −1 for the model protein ovalbumin. The PPF was applied to the selective capture and isolation of ovalbumin from complex biological samples. Graphical abstract Super-hydrophilic poly-polyhedral oligomeric silsesquioxane formaldehyde (PPF) is prepared via a catalyst-free polymerization route. PPF exhibits high capturing and adsorption selectivity towards glycoproteins due to its strong hydrophilic interaction with glycan groups. Favorable capturing capacity is also achieved.
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-017-2100-z