Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel

The current study is aimed to prepare 99m Tc-lidocaine as a new myocardial perfusion-imaging agent. The used 99m Tc was obtained from Al– 99 Mo-molybdate(VI) gel matrix. 99m Tc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied 99m...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2017, Vol.314 (3), p.2091-2098
Main Authors: Sakr, Tamer M., Ibrahim, A. B., Fasih, T. W., Rashed, H. M.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heart
Heavy Ions
Inorganic Chemistry
Molybdenum isotopes
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Selectivity
Technetium isotopes
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Summary:The current study is aimed to prepare 99m Tc-lidocaine as a new myocardial perfusion-imaging agent. The used 99m Tc was obtained from Al– 99 Mo-molybdate(VI) gel matrix. 99m Tc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied 99m Tc-valsartan and 99m Tc-procainamide. Consequently, 99m Tc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99m Tc-lidocaine for sodium channels in the heart.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-017-5560-z