Synthesis and Analgesic Activity of 5,7- and 6-Substituted Diazaadamantanes Containing Monoterpene Moieties

A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Anoth...

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Bibliographic Details
Published in:Chemistry of natural compounds 2017-11, Vol.53 (6), p.1131-1136
Main Authors: Ponomarev, K. Yu, Morozova, E. A., Suslov, E. V., Korchagina, D. V., Tolstikova, T. G., Volcho, K. P., Salakhutdinov, N. F.
Format: Article
Language:English
Subjects:
Aldehydes
Analgesics
Analogs
Biological activity
Carbonyls
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Plates (structural members)
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Summary:A series of new compounds combining diazaadamantane and monoterpene moieties that were analogs of highly potent analgesic substituted 5,7-dimethyl-1,3-diazaadamantan-6-ones were prepared by reacting 1,5-diethyl- and 1,5-dipropyl-3,7-diazabicyclo[3.3.1]nonan-9-ones with monoterpenoid aldehydes. Another two structural analogs of these compounds were synthesized by reducing the carbonyl. The biological activity of the prepared compounds was studied in hot-plate and acetate-writhing tests.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-017-2216-8