Gemcitabine and carboplatin in metastatic nonsmall cell lung cancer: Experience from a tertiary cancer center in South India

BACKGROUND: Gemcitabine and carboplatin combination is widely used as one of the first-line chemotherapeutic regimens in patients with metastatic nonsmall cell lung cancer patients. METHODOLOGY: A total of 112 patients with metastatic disease were recruited. They were on standard 21-day gemcitabine...

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Bibliographic Details
Published in:Indian journal of cancer 2017-01, Vol.54 (1), p.169
Main Authors: Devika, T, Dubashi, B, Shewade, D, Kayal, S, Kumar, Rcs
Format: Article
Language:English
Subjects:
Anemia
Cancer metastasis
Cancer therapies
Carboplatin
Chemotherapy
Clinical trials
Drug therapy
Gemcitabine
Health education
Hematology
Lung cancer
Metastasis
Non-small cell lung cancer
Oncology
Patient outcomes
Response rates
Survival analysis
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Summary:BACKGROUND: Gemcitabine and carboplatin combination is widely used as one of the first-line chemotherapeutic regimens in patients with metastatic nonsmall cell lung cancer patients. METHODOLOGY: A total of 112 patients with metastatic disease were recruited. They were on standard 21-day gemcitabine 1.2 g/m2 and carboplatin AUC 5 dosing schedule. Each patient received at least four cycles and a maximum of 6 cycles of treatment. The patients were followed up, and the demographic, efficacy and toxicity profiles were analyzed. RESULT: The mean age was 53.81+-9.85 with 71 male and 41 female patients. Response assessment was done in 82 patients, and the objective response rate was found to be 47.6% with 39 partial responders, 20 patients with stable disease and 23 patients with progressive disease. The median overall survival was 12 months (95% CI 9.89-14.11). We found anemia (62.5%) to be more prominent than the other toxicities followed by thrombocytopenia and vomiting (31.3%). The nonhematological toxicities were minimal and manageable. CONCLUSION: Treatment with gemcitabine and carboplatin is efficacious with manageable toxicity profile in the real world non-clinical trial setting.
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.IJC_28_17