Squamous cell carcinoma on vitiligo patch: A rare association

Vitiligo is an immune-mediated disease characterized by idiopathic destruction of melanocyte. The loss of pigment melanin predisposes vitiligo patients to photosensitivity and early photodamage. Despite this, the incidence of squamous cell carcinoma (SCC) is not found to be increased in vitiligo. SC...

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Bibliographic Details
Published in:Pigment international (Online) 2017-07, Vol.4 (2), p.115
Main Authors: Vijay, Anita, Jain, Suresh, Kumar, Ramesh
Format: Article
Language:English
Subjects:
Cancer
Carcinoma
Dermatology
Free radicals
Melanoma
Patients
Radiation (Physics)
Skin cancer
Squamous cell carcinoma
Superoxides
Tumor necrosis factor
Tumor proteins
Ultraviolet radiation
Vitiligo
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Summary:Vitiligo is an immune-mediated disease characterized by idiopathic destruction of melanocyte. The loss of pigment melanin predisposes vitiligo patients to photosensitivity and early photodamage. Despite this, the incidence of squamous cell carcinoma (SCC) is not found to be increased in vitiligo. SCC is a common malignancy of keratinocytes that arises in sites of exposure to excessive ultraviolet radiation. Various theories have been proposed for lower incidence of SCC in vitiligo. These include decrease in cytokines, such as transforming growth factor-β and IL-10, along with increase in IL-1, TNF-α, p53, superoxide dismutase, and glutathione peroxidase. We hereby report a rare case of SCC arising in a patient with longstanding vitiligo of photoprotected skin with no history of phototherapy.
ISSN:2349-5847
2349-5847
DOI:10.4103/2349-5847.219682