Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice

• Published in: Plant foods for human nutrition (Dordrecht) 2017-12, Vol.72 (4), p.445-447
• Main Authors: Luna-Vital, Diego A., González de Mejía, Elvira, Loarca-Piña, Guadalupe
• Format: Article
• Language: English
• Subjects: Animals; Azoxymethane; Azoxymethane - toxicity; Carcinogenesis; Carcinogens; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Colitis; Colitis - chemically induced; Colitis - complications; Colitis - prevention & control; Colon; Colonic Neoplasms - chemically induced; Colonic Neoplasms - drug therapy; Dextran; Dextran Sulfate - toxicity; Diet; Dietary Proteins - pharmacology; Ecology; Food Science; French beans; Inflammatory bowel disease; Mice; Mice, Inbred BALB C; Neoplasms; Nutrition; Peptides; Phaseolus - chemistry; Phaseolus vulgaris; Plant Extracts - chemistry; Plant Physiology; Rodents; Short Communication; Sodium; Sodium sulfate; Sulfates; Tumors
• ISSN: 0921-9668; 1573-9104
• DOI: 10.1007/s11130-017-0633-2

The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased ( p