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Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice
The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon...
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| Published in: | Plant foods for human nutrition (Dordrecht) 2017-12, Vol.72 (4), p.445-447 |
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| cites | cdi_FETCH-LOGICAL-c372t-cdd04142f29c5a109898f1583feb3f27617e6a1f12e67dc5254add879671c67c3 |
| container_end_page | 447 |
| container_issue | 4 |
| container_start_page | 445 |
| container_title | Plant foods for human nutrition (Dordrecht) |
| container_volume | 72 |
| creator | Luna-Vital, Diego A. González de Mejía, Elvira Loarca-Piña, Guadalupe |
| description | The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased (
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| doi_str_mv | 10.1007/s11130-017-0633-2 |
| format | article |
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p
< 0.05) the disease activity index (DAI) compared to C+ (5.8, 9.1, 11.8, respectively). Furthermore, AH reduced the number of evident neoplasms compared to group C+ (1.8, 5.9 neoplasms/mice, respectively). The results suggest that peptides from common bean cv. Azufrado Higuera could prevent colitis-associated colon carcinogenesis.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1007/s11130-017-0633-2</identifier><identifier>PMID: 28965253</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Azoxymethane ; Azoxymethane - toxicity ; Carcinogenesis ; Carcinogens ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Colitis ; Colitis - chemically induced ; Colitis - complications ; Colitis - prevention & control ; Colon ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - drug therapy ; Dextran ; Dextran Sulfate - toxicity ; Diet ; Dietary Proteins - pharmacology ; Ecology ; Food Science ; French beans ; Inflammatory bowel disease ; Mice ; Mice, Inbred BALB C ; Neoplasms ; Nutrition ; Peptides ; Phaseolus - chemistry ; Phaseolus vulgaris ; Plant Extracts - chemistry ; Plant Physiology ; Rodents ; Short Communication ; Sodium ; Sodium sulfate ; Sulfates ; Tumors</subject><ispartof>Plant foods for human nutrition (Dordrecht), 2017-12, Vol.72 (4), p.445-447</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-cdd04142f29c5a109898f1583feb3f27617e6a1f12e67dc5254add879671c67c3</citedby><cites>FETCH-LOGICAL-c372t-cdd04142f29c5a109898f1583feb3f27617e6a1f12e67dc5254add879671c67c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28965253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luna-Vital, Diego A.</creatorcontrib><creatorcontrib>González de Mejía, Elvira</creatorcontrib><creatorcontrib>Loarca-Piña, Guadalupe</creatorcontrib><title>Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice</title><title>Plant foods for human nutrition (Dordrecht)</title><addtitle>Plant Foods Hum Nutr</addtitle><addtitle>Plant Foods Hum Nutr</addtitle><description>The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased (
p
< 0.05) the disease activity index (DAI) compared to C+ (5.8, 9.1, 11.8, respectively). Furthermore, AH reduced the number of evident neoplasms compared to group C+ (1.8, 5.9 neoplasms/mice, respectively). The results suggest that peptides from common bean cv. Azufrado Higuera could prevent colitis-associated colon carcinogenesis.</description><subject>Animals</subject><subject>Azoxymethane</subject><subject>Azoxymethane - toxicity</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - complications</subject><subject>Colitis - prevention & control</subject><subject>Colon</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Dextran</subject><subject>Dextran Sulfate - toxicity</subject><subject>Diet</subject><subject>Dietary Proteins - pharmacology</subject><subject>Ecology</subject><subject>Food Science</subject><subject>French beans</subject><subject>Inflammatory bowel disease</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasms</subject><subject>Nutrition</subject><subject>Peptides</subject><subject>Phaseolus - chemistry</subject><subject>Phaseolus vulgaris</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Physiology</subject><subject>Rodents</subject><subject>Short Communication</subject><subject>Sodium</subject><subject>Sodium sulfate</subject><subject>Sulfates</subject><subject>Tumors</subject><issn>0921-9668</issn><issn>1573-9104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE9v1DAQxS0EokvhA3BBlji767ETOz4uW_5U2qoVhbPltSeLq2y82AkSfHpcpSAunEYz894bzY-Q18AvgHO9LgAgOeOgGVdSMvGErKDVkhngzVOy4kYAM0p1Z-RFKfe8epRqn5Mz0RnVilauyK_LiJPLP-ktnqYYsNA-pyO9_eYKpmEu9Mc8HFyOhe4u6GcMs8dANzfX68u7O3Y1Lv02DXGKhW1KST66aRmlkW5d9nFMBxyx1Ig40ndu2K89vY4eX5JnvRsKvnqs5-Trh_dftp_Y7ubj1XazY15qMTEfAm-gEb0wvnXATWe6HtpO9riXvdAKNCoHPQhUOvj6VuNC6LRRGrzSXp6Tt0vuKafvM5bJ3qc5j_WkBaMlbzqQTVXBovI5lZKxt6ccj5WMBW4faNuFtq207QNtK6rnzWPyvD9i-Ov4g7cKxCIodTUeMP9z-r-pvwH3kYk_</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Luna-Vital, Diego A.</creator><creator>González de Mejía, Elvira</creator><creator>Loarca-Piña, Guadalupe</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171201</creationdate><title>Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice</title><author>Luna-Vital, Diego A. ; González de Mejía, Elvira ; Loarca-Piña, Guadalupe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-cdd04142f29c5a109898f1583feb3f27617e6a1f12e67dc5254add879671c67c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Azoxymethane</topic><topic>Azoxymethane - toxicity</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Colitis</topic><topic>Colitis - chemically induced</topic><topic>Colitis - complications</topic><topic>Colitis - prevention & control</topic><topic>Colon</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Dextran</topic><topic>Dextran Sulfate - toxicity</topic><topic>Diet</topic><topic>Dietary Proteins - pharmacology</topic><topic>Ecology</topic><topic>Food Science</topic><topic>French beans</topic><topic>Inflammatory bowel disease</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neoplasms</topic><topic>Nutrition</topic><topic>Peptides</topic><topic>Phaseolus - chemistry</topic><topic>Phaseolus vulgaris</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Physiology</topic><topic>Rodents</topic><topic>Short Communication</topic><topic>Sodium</topic><topic>Sodium sulfate</topic><topic>Sulfates</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luna-Vital, Diego A.</creatorcontrib><creatorcontrib>González de Mejía, Elvira</creatorcontrib><creatorcontrib>Loarca-Piña, Guadalupe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luna-Vital, Diego A.</au><au>González de Mejía, Elvira</au><au>Loarca-Piña, Guadalupe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><stitle>Plant Foods Hum Nutr</stitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>72</volume><issue>4</issue><spage>445</spage><epage>447</epage><pages>445-447</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>The aim was to evaluate the antineoplastic potential of a previously characterized peptide extract from the non-digestible fraction of common bean cv. Azufrado Higuera (AH) and its most abundant pure peptide GLTSK, in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colon carcinogenesis Balb/c mice model. The healthy control (C-) had no induction and no treatment, and the induced control (C+) had induction but no treatment. Groups AH and GLTSK were administered 50 mg/kg-bw of AH or GLTSK, respectively. The administration of AH and GLTSK decreased (
p
< 0.05) the disease activity index (DAI) compared to C+ (5.8, 9.1, 11.8, respectively). Furthermore, AH reduced the number of evident neoplasms compared to group C+ (1.8, 5.9 neoplasms/mice, respectively). The results suggest that peptides from common bean cv. Azufrado Higuera could prevent colitis-associated colon carcinogenesis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28965253</pmid><doi>10.1007/s11130-017-0633-2</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Azoxymethane Azoxymethane - toxicity Carcinogenesis Carcinogens Chemistry Chemistry and Materials Science Chemistry/Food Science Colitis Colitis - chemically induced Colitis - complications Colitis - prevention & control Colon Colonic Neoplasms - chemically induced Colonic Neoplasms - drug therapy Dextran Dextran Sulfate - toxicity Diet Dietary Proteins - pharmacology Ecology Food Science French beans Inflammatory bowel disease Mice Mice, Inbred BALB C Neoplasms Nutrition Peptides Phaseolus - chemistry Phaseolus vulgaris Plant Extracts - chemistry Plant Physiology Rodents Short Communication Sodium Sodium sulfate Sulfates Tumors |
| title | Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice |
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