Liver dysfunction in severe ovarian hyperstimulation syndrome

• Published in: Gynecological endocrinology 2005-07, Vol.21 (1), p.45-49
• Main Authors: Obrzut, Bogdan, Kuczy ski, Waldemar, Grygoruk, Cezary, Putowski, Lechos aw, Kluz, Sabina, Skr t, Andrzej
• Format: Article
• Language: English
• Subjects: Adult; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Biopsy; Chorionic Gonadotropin - administration & dosage; Female; Humans; in vitro fertilization; Liver Diseases - diagnosis; Liver Diseases - etiology; Liver Diseases - pathology; liver dysfunction; Menotropins - administration & dosage; Ovarian hyperstimulation syndrome; Ovarian Hyperstimulation Syndrome - complications; Ovarian Hyperstimulation Syndrome - diagnosis; Ovarian Hyperstimulation Syndrome - therapy; Ovulation Induction - adverse effects; Pregnancy; Pregnancy Outcome
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590500099511

We report the case of a 32-year-old woman suffering from severe liver dysfunction in the course of ovarian hyperstimulation syndrome (OHSS). Complications occurred after successful fertilization subsequent to ovarian stimulation with human menopausal gonadotropin followed by ovulation induction with human chorionic gonadotropin. Because of nausea, vomiting, abdominal distention and enlarged ovaries on an ultrasound examination, she was admitted on the diagnosis of OHSS. During the course of hospitalization severe hepatic injury developed. An increase of more than 100-fold in blood aminotransferase activity was observed. Applied treatment resulted in gradual reduction of ovarian size and resolution of ascites, as well as pleural and pericardial effusions. The patient was discharged from hospital after 46 days. Follow-up examinations at the 13th and 32nd weeks of gestation did not reveal any abnormalities. Pregnancy developed without complications and the woman went into spontaneous labor, giving birth to a viable child at 38 weeks' gestation. Taking into account the above case and previously published reports, the issue of liver dysfunction may have a great impact on the understanding both the pathology and the treatment of OHSS.