Disorders of sex development: Hormonal management in adolescence

Hormonal treatment represents the principal aspect of clinical management of people with disorders of sex development (DSD) from adolescence onwards. In fact, individuals with DSD may require sex steroid replacement to induce secondary sex characteristics, to optimize bone mass accrual, and to promo...

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Bibliographic Details
Published in:Gynecological endocrinology 2008-01, Vol.24 (6), p.339-346
Main Authors: Bertelloni, Silvano, Dati, Eleonora, Baroncelli, Giampiero I.
Format: Article
Language:English
Subjects:
adolescence
Adolescent
Bone and Bones - drug effects
Bone and Bones - metabolism
bone health
Disorders of sex development
Disorders of Sex Development - drug therapy
Disorders of Sex Development - metabolism
estrogens
Estrogens - administration & dosage
Female
Hormone Replacement Therapy - methods
Humans
Hypogonadism - drug therapy
Hypogonadism - metabolism
Male
sex steroid substitutive therapy
testosterone
Testosterone - administration & dosage
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Summary:Hormonal treatment represents the principal aspect of clinical management of people with disorders of sex development (DSD) from adolescence onwards. In fact, individuals with DSD may require sex steroid replacement to induce secondary sex characteristics, to optimize bone mass accrual, and to promote physical and social well-being. Testosterone is the main hormone for treatment in males and estrogens in females. The optimal regimens for sex steroid substitutive therapy in subjects with DSD should be better defined in multi-center prospective studies. Bone health remains a crucial aspect in the management of these persons, but few sound data are available to guide clinical practice.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590802055708