Luteal estrogen supplementation in stimulated cycles may improve the pregnancy rate in patients undergoing in vitro fertilization intracytoplasmic sperm injection-embryo transfer

Objective. To evaluate the effect of estradiol addition to progesterone supplementation during the luteal phase on pregnancy and implantation rates in patients undergoing in vitro fertilization intracytoplasmic sperm injection-embryo transfer (IVF ICSI-ET) cycles. Methods. In this prospective, rando...

Full description

Saved in:
Bibliographic Details
Published in:Gynecological endocrinology 2007-11, Vol.23 (11), p.645-652
Main Authors: Drakakis, Peter, Loutradis, Dimitris, Vomvolaki, Eleftheria, Stefanidis, Konstantinos, Kiapekou, Erasmia, Anagnostou, Elli, Anastasiadou, Kiki, Milingos, Spiros, Antsaklis, Aris
Format: Article
Language:English
Subjects:
Adult
Embryo Implantation
Embryo Transfer
Estradiol - administration & dosage
Estradiol supplementation
Female
Fertilization in Vitro
Humans
in vitro fertilization/intracytoplasmic sperm injection
Infertility - etiology
Infertility - therapy
Luteal Phase
luteal support
Ovulation Induction - methods
Pregnancy
pregnancy rate
Progesterone - administration & dosage
Prospective Studies
Sperm Injections, Intracytoplasmic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. To evaluate the effect of estradiol addition to progesterone supplementation during the luteal phase on pregnancy and implantation rates in patients undergoing in vitro fertilization intracytoplasmic sperm injection-embryo transfer (IVF ICSI-ET) cycles. Methods. In this prospective, randomized study, carried out in an IVF unit of a university hospital, we studied patients who were undergoing IVF ICSI with controlled ovarian hyperstimulation using a gonadotropin-releasing hormone agonist human recombinant gonadotropin long protocol. The main outcome measures were the pregnancy and implantation rates measured in the two groups. Results. Our results suggest higher pregnancy and implantation rates in IVF ICSI-ET cycles that were supplemented with estradiol in the luteal phase. Conclusions. Estradiol supplementation during the luteal phase in women undergoing IVF ICSI-ET has a beneficial effect on the outcome without (at least, as seems from this study) having any adverse effects.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590701664923