Serum anti-Müllerian hormone levels differentiate control from subfertile men but not men with different causes of subfertility

Aim. To determine stimulated serum anti-Müllerian hormone (AMH) levels in men with different causes of subfertility. Subjects and methods. We prospectively studied 82 subfertile men and 31 controls. The subfertile men underwent a diagnostic procedure to identify the causes of subfertility. Study par...

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Bibliographic Details
Published in:Gynecological endocrinology 2008-01, Vol.24 (3), p.158-160
Main Authors: Goulis, Dimitrios G., Iliadou, Paschalia K., Tsametis, Christos, Gerou, Spyridon, Tarlatzis, Basil C., Bontis, Ioannis N., Papadimas, Ioannis
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone - blood
Anti-Müllerian hormone
Azoospermia - blood
Cryptorchidism - complications
Humans
Infertility, Male - blood
Infertility, Male - etiology
inhibin B
Male
male infertility
Prospective Studies
Sperm Count
Sperm Motility
Spermatozoa - abnormalities
Varicocele - complications
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Summary:Aim. To determine stimulated serum anti-Müllerian hormone (AMH) levels in men with different causes of subfertility. Subjects and methods. We prospectively studied 82 subfertile men and 31 controls. The subfertile men underwent a diagnostic procedure to identify the causes of subfertility. Study parameters included testicular volume, levels of follicle-stimulating hormone, luteinizing hormone, total testosterone, prolactin, inhibin B and AMH, and sperm parameters. Results. Clinical diagnoses in subfertile men were idiopathic non-obstructive azoospermia (n = 26, 32%), idiopathic non-obstructive dyspermia (n = 17, 21%), varicocele (n = 16, 20%), cryptorchidism (n = 10, 12%) and other diagnoses (n = 13, 16%). Serum AMH levels in subfertile men were 60% lower than in controls [median (interquartile range) 4.6 (3.6) vs. 11.6 (7.7) ng ml, p < 0.001], with no significant differences among the different groups of subfertile men. Conclusions. Serum AMH levels differentiate control from subfertile men but not men with different causes of subfertility.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590701672314