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Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium
ABSTRACT Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron mi...
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Published in: | Journal of applied polymer science 2018-03, Vol.135 (12), p.n/a |
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description | ABSTRACT
Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X‐ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro‐resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919. |
doi_str_mv | 10.1002/app.45919 |
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Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X‐ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro‐resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.45919</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Controlled release ; Diclofenac ; Drug delivery systems ; Electron microscopy ; Entrapment ; Erosion mechanisms ; Formulations ; Fourier transforms ; Gelation ; Infrared analysis ; Materials science ; Mathematical analysis ; Matrix methods ; Nonsteroidal anti-inflammatory drugs ; Polymers ; polysaccharides ; proteins</subject><ispartof>Journal of applied polymer science, 2018-03, Vol.135 (12), p.n/a</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2979-47f4e8546a0a77b278ab7aa0f707bb047fc4159c3f071cde35945efc4a1514823</citedby><cites>FETCH-LOGICAL-c2979-47f4e8546a0a77b278ab7aa0f707bb047fc4159c3f071cde35945efc4a1514823</cites><orcidid>0000-0003-1880-7673</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Vidart, Jacyara Moreira Martins</creatorcontrib><creatorcontrib>Silva, Thiago Lopes da</creatorcontrib><creatorcontrib>Rosa, Paulo César Pires</creatorcontrib><creatorcontrib>Vieira, Melissa Gurgel Adeodato</creatorcontrib><creatorcontrib>Silva, Meuris Gurgel Carlos da</creatorcontrib><title>Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium</title><title>Journal of applied polymer science</title><description>ABSTRACT
Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X‐ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro‐resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919.</description><subject>Controlled release</subject><subject>Diclofenac</subject><subject>Drug delivery systems</subject><subject>Electron microscopy</subject><subject>Entrapment</subject><subject>Erosion mechanisms</subject><subject>Formulations</subject><subject>Fourier transforms</subject><subject>Gelation</subject><subject>Infrared analysis</subject><subject>Materials science</subject><subject>Mathematical analysis</subject><subject>Matrix methods</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Polymers</subject><subject>polysaccharides</subject><subject>proteins</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kD9PwzAQxS0EEqUw8A0sMTGktRO7jseq_JUq0QHmyHEurSs3DrYD6rfHJaxMd7r3u3enh9AtJTNKSD5XfT9jXFJ5hiaUSJGxRV6eo0nSaFZKyS_RVQh7QijlZDFBwwN8gXX9AbqIXYsDeKNNN1d2azoVAffKR6MtBFwfsXGd0XgLVsXU4gh615nPAXDrPI47wNp10TtrocEeLKgAJ9MmGbgWOqVxcI0ZDtfoolU2wM1fnaKPp8f31Uu2fnt-XS3Xmc6lkBkTLYOSs4UiSog6F6WqhVKkFUTUNUmyZpRLXbREUN1AwSXjkIaKcsrKvJiiu9G39y69GWK1d4Pv0smKSsElL3hJE3U_Utq7EDy0Ve_NQfljRUl1SrVKqVa_qSZ2PrLfxsLxf7Babjbjxg_BOHrZ</recordid><startdate>20180320</startdate><enddate>20180320</enddate><creator>Vidart, Jacyara Moreira Martins</creator><creator>Silva, Thiago Lopes da</creator><creator>Rosa, Paulo César Pires</creator><creator>Vieira, Melissa Gurgel Adeodato</creator><creator>Silva, Meuris Gurgel Carlos da</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-1880-7673</orcidid></search><sort><creationdate>20180320</creationdate><title>Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium</title><author>Vidart, Jacyara Moreira Martins ; Silva, Thiago Lopes da ; Rosa, Paulo César Pires ; Vieira, Melissa Gurgel Adeodato ; Silva, Meuris Gurgel Carlos da</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2979-47f4e8546a0a77b278ab7aa0f707bb047fc4159c3f071cde35945efc4a1514823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Controlled release</topic><topic>Diclofenac</topic><topic>Drug delivery systems</topic><topic>Electron microscopy</topic><topic>Entrapment</topic><topic>Erosion mechanisms</topic><topic>Formulations</topic><topic>Fourier transforms</topic><topic>Gelation</topic><topic>Infrared analysis</topic><topic>Materials science</topic><topic>Mathematical analysis</topic><topic>Matrix methods</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Polymers</topic><topic>polysaccharides</topic><topic>proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vidart, Jacyara Moreira Martins</creatorcontrib><creatorcontrib>Silva, Thiago Lopes da</creatorcontrib><creatorcontrib>Rosa, Paulo César Pires</creatorcontrib><creatorcontrib>Vieira, Melissa Gurgel Adeodato</creatorcontrib><creatorcontrib>Silva, Meuris Gurgel Carlos da</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vidart, Jacyara Moreira Martins</au><au>Silva, Thiago Lopes da</au><au>Rosa, Paulo César Pires</au><au>Vieira, Melissa Gurgel Adeodato</au><au>Silva, Meuris Gurgel Carlos da</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium</atitle><jtitle>Journal of applied polymer science</jtitle><date>2018-03-20</date><risdate>2018</risdate><volume>135</volume><issue>12</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>ABSTRACT
Sericin and alginate particles, prepared by ionic gelation technique, demonstrated to be a promising matrix to controlled release of diclofenac sodium. Ten particle compositions of sericin, alginate, and diclofenac were evaluated. The drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X‐ray diffraction analysis. In vitro dissolution profile was performed to obtain the drug release profile in gastric and enteric medium. The drug release profile indicated that sericin delays the release and alginate contributes to the gastro‐resistance of formulations. The blend with composition of 2.5% of sericin, 2.8% of alginate with 2.0% w/v of diclofenac demonstrated to be feasible for drug delivery due the entrapment efficiency of 81.06% and release delay of 360 min, the highest time of all investigated compositions. The mathematical modeling showed that the drug release mechanism is associated to the process of swelling, matrix erosion, and a combination of diffusion and chain relaxation mechanisms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45919.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/app.45919</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1880-7673</orcidid></addata></record> |
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subjects | Controlled release Diclofenac Drug delivery systems Electron microscopy Entrapment Erosion mechanisms Formulations Fourier transforms Gelation Infrared analysis Materials science Mathematical analysis Matrix methods Nonsteroidal anti-inflammatory drugs Polymers polysaccharides proteins |
title | Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium |
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