The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline

Oxidative stress had a great importance in development of complications in diabetes. We investigated effects of melatonin and pentoxifylline in diabetic mice. Swiss albino mice (n = 40) were divided into four groups: alloxan‐induced diabetes mellitus (DM), alloxan‐induced diabetes with melatonin sup...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2017-12, Vol.31 (12), p.n/a
Main Authors: Şekeroğlu, Mehmet Ramazan, Huyut, Zübeyir, Çokluk, Erdem, Özbek, Hanefi, Alp, Hamit Hakan
Format: Article
Language:English
Subjects:
Alloxan
Animals
antioxidant enzymes
Antioxidants
Autoxidation
Complications
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - drug therapy
Drug Evaluation, Preclinical
Erythrocytes
Erythrocytes - drug effects
Erythrocytes - metabolism
Free Radical Scavengers - pharmacology
Free Radical Scavengers - therapeutic use
Glutathione
Glutathione Peroxidase - blood
Malondialdehyde
Melatonin
Melatonin - pharmacology
Melatonin - therapeutic use
Mice
Oxidation
Oxidation-Reduction
Oxidative Stress
pentoxifylline
Pentoxifylline - pharmacology
Pentoxifylline - therapeutic use
Peroxidase
RBC
Rodents
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Summary:Oxidative stress had a great importance in development of complications in diabetes. We investigated effects of melatonin and pentoxifylline in diabetic mice. Swiss albino mice (n = 40) were divided into four groups: alloxan‐induced diabetes mellitus (DM), alloxan‐induced diabetes with melatonin supplementation (DM + MLT), alloxan‐induced diabetes with pentoxifylline supplementation (DM + PTX), and control. Glutathione‐peroxidase (GSH‐Px) activity, malondialdehyde (MDA) and reduced glutathione (GSH) levels, and susceptibility to oxidation of erythrocytes were measured. MDA levels were higher than control in the DM and DM + MLT. The DM had more MDA level than the DM + MLT and DM + PTX (P 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.21976