Analysis of the Specificity of IgA Antibodies Produced in the Mouse Small Intestine

Intestinal microbiota controls multiple aspects of body homeostasis. The microbiota composition changes easily in response to internal or external factors, which may result in dysbiosis and associated inflammatory reactions. Thus, maintaining the microbiota composition by the host immune system is c...

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Bibliographic Details
Published in:Molecular biology (New York) 2017-11, Vol.51 (6), p.813-818
Main Authors: Sharanova, N. E., Ninnemann, J., Bondareva, M. A., Semin, Y. K., Nomokonova, A. V., Kruglov, A. A.
Format: Article
Language:English
Subjects:
Bacteria
Biochemistry
Biomedical and Life Sciences
Cell lines
Current Trends in the Application of Monoclonal Antibodies Special Issue
Dysbacteriosis
Homeostasis
Human Genetics
Immune system
Immunoglobulin A
Immunoglobulins
Inflammation
Intestinal microflora
Life Sciences
Microbiota
Molecular modelling
Monoclonal antibodies
Mucosa
Rodents
Small intestine
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Summary:Intestinal microbiota controls multiple aspects of body homeostasis. The microbiota composition changes easily in response to internal or external factors, which may result in dysbiosis and associated inflammatory reactions. Thus, maintaining the microbiota composition by the host immune system is crucial, and one of the main mechanisms for microbiota control is production of immunoglobulin A (IgA) at mucosal surfaces. The molecular mechanisms regulating the interactions between the immune system and microbiota remain obscure. A panel of hybridoma cell lines was constructed to produce monoclonal IgA antibodies specific to various commensal bacteria present in intestinal microbiota. The panel can be used to further understand the mechanisms whereby the adaptive immune system controls the microbiota composition.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893317060152