Influence of calcium carbonate and sodium carbonate gassing agents on pentoxifylline floating tablets properties

This study was to design and evaluate effervescent floating tablets with sustained release behaviour. Pentoxifylline is a water-soluble model drug with a short half-life, consequently developing sustained release preparations would be beneficial. A binary (1:1) mixture of sodium alginate and hydroxy...

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Bibliographic Details
Published in:Powder technology 2017-12, Vol.322, p.65-74
Main Authors: Rahim, Safwan Abdel, Carter, Paul, Elkordy, Amal Ali
Format: Article
Language:English
Subjects:
Alginic acid
Calcium
Calcium carbonate
Cellulose
Controlled release
Drug delivery systems
Drugs
Floating
Floating tablets
Hydroxyethyl cellulose
Hydroxyethyl celluloses
In vivo methods and tests
Lag time
Mechanical properties
Oral administration
Pentoxifylline
Pharmacology
Rats
Sodium
Sodium alginate
Sodium carbonate
Studies
Sustained release
Tablets
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Summary:This study was to design and evaluate effervescent floating tablets with sustained release behaviour. Pentoxifylline is a water-soluble model drug with a short half-life, consequently developing sustained release preparations would be beneficial. A binary (1:1) mixture of sodium alginate and hydroxyethyl cellulose containing pentoxifylline, with either 10% or 20% calcium carbonate or sodium carbonate, was used to prepare floating tablets. Tablets floated on the surface of the dissolution medium, showed an adequate floating lag time, and floated for more than 12 hours. Tablets manufactured from granules with 20%(w/w) calcium carbonate were promising with respect to their floating lag time (~7min), floating duration (>24 hours), sustained drug release rate, and swelling ability. An in vivo study of these promising tablets and a reference solution of pentoxifylline were investigated following oral administration of 5.75±0.15mg in rats. Compared with the reference solution, the pharmacokinetic parameters changed significantly (p
ISSN:0032-5910
1873-328X
DOI:10.1016/j.powtec.2017.09.001