Facile fabrication of polylactic acid stereocomplex microspheres

[Display omitted] •Polylactic acid stereocomplex microspheres were prepared by one-pot process.•This method is easy and scalable.•One polylactic acid molecule has both PLLA and PDLA arms. An efficient and scalable method to prepare polylactic acid stereocomplex microspheres (sc-PLA-MPs) is achieved....

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Bibliographic Details
Published in:Materials letters 2018-01, Vol.211, p.146-148
Main Authors: Chen, Zhize, Chang, Yue, Jiang, Ziyan
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradable materials
Chemical synthesis
Coupling (molecular)
Crystal structure
Low molecular weights
Materials science
Microparticles
Microspheres
Polylactic acid
Powder technology
Structural
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Summary:[Display omitted] •Polylactic acid stereocomplex microspheres were prepared by one-pot process.•This method is easy and scalable.•One polylactic acid molecule has both PLLA and PDLA arms. An efficient and scalable method to prepare polylactic acid stereocomplex microspheres (sc-PLA-MPs) is achieved. Low molecular weight polylactic acid containing triethoxysilane end-groups (Si-PLA) were firstly synthesized via coupling reaction of 3-(triethoxysilyl)propyl isocyanate with low molecular weight poly (l-lactic acid) (PLLA) and poly (D-lactic acid) (PDLA). Then, the triethoxysilane terminated poly (l-lactic acid) and poly (d-lactic acid) were dissolved in 1,4-dioxane where the triethoxysilane end-groups could hydrolytic condense in-situ, leading to the formation of the architecture having both PLLA and PDLA arms in one molecule, and consequently the stereocomplex microparticles spontaneously precipitated in the form of spherical microspheres with size of approximately ∼5μm.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2017.09.089