Ruthenium‐Catalyzed Difluoroalkylation of 8‐Aminoquinoline Amides at the C5‐Position

A ruthenium‐catalyzed highly selective difluoromethylation of 8‐aminoquinoline amides at the C5 position has been developed. It tolerates a broad range of functional groups, providing the corresponding difluoromethylated products in moderate to good yields. Preliminary experimental results indicate...

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Published in:European journal of organic chemistry 2017-12, Vol.2017 (46), p.6947-6950
Main Authors: Chen, Changpeng, Zeng, Runsheng, Zhang, Jingyu, Zhao, Yingsheng
Format: Article
Language:English
Subjects:
Amides
Aminoquinolines
Fluorinated Compounds
Fluorine
Functional groups
Homogeneous catalysis
Ruthenium
Selectivity
Synthetic methods
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description A ruthenium‐catalyzed highly selective difluoromethylation of 8‐aminoquinoline amides at the C5 position has been developed. It tolerates a broad range of functional groups, providing the corresponding difluoromethylated products in moderate to good yields. Preliminary experimental results indicate that the tricoordinate ruthenium intermediate is the key factor in achieving the C5‐position selectivity. A ruthenium‐catalyzed highly selective difluoromethylation of 8‐aminoquinoline amides at the C5 position has been developed. It tolerates a broad range of functional groups, providing the corresponding difluoromethylated products in moderate to good yields.
doi_str_mv 10.1002/ejoc.201701150
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source Wiley-Blackwell Read & Publish Collection
subjects Amides
Aminoquinolines
Fluorinated Compounds
Fluorine
Functional groups
Homogeneous catalysis
Ruthenium
Selectivity
Synthetic methods
title Ruthenium‐Catalyzed Difluoroalkylation of 8‐Aminoquinoline Amides at the C5‐Position
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