Simple and efficient method for aromatization of tetrahydro-β-carbolines by using K2S2O8 as a catalyst and its antimicrobial activity comparison with molecular docking studies

A novel and efficient aromatization of tetrahydro-β-carbolines under mild conditions using K 2 S 2 O 8 as a catalyst was developed. The method is applicable for all kinds of C 1 substituted systems. All synthesized compounds were screened for their in vitro antibacterial activity against Staphylococ...

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Bibliographic Details
Published in:Russian journal of general chemistry 2017-11, Vol.87 (11), p.2703-2711
Main Authors: Kurumanna, A., Ashok, K., Rambabu, S., Sonyanaik, B., Ravi, D., Madhu, P., Sakram, B.
Format: Article
Language:English
Subjects:
Catalysis
Catalysts
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
E coli
Fungicides
Fusarium
Fusarium oxysporum
Klebsiella
Molecular docking
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Summary:A novel and efficient aromatization of tetrahydro-β-carbolines under mild conditions using K 2 S 2 O 8 as a catalyst was developed. The method is applicable for all kinds of C 1 substituted systems. All synthesized compounds were screened for their in vitro antibacterial activity against Staphylococus aureus , Bacillus subtilis , Escherichia coli , and Klebsiella pneumonia , as well as fungi, such as Aspergillus flavus and Fusarium oxysporum . Compounds 4b , 4g , 4i , and 4k demonstrated excellent in vitro antibacterial and antifungal activities than the standard drugs. The docking studies were carried out for most active compounds 4b , 4g , 4i , and 4k .
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217110287