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A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacteria...
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| Published in: | Angewandte Chemie 2017-12, Vol.129 (52), p.16773-16776 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c2020-58329d11bd1da39867b43ae13bcf97e721733080c3ef0b0d68eb20d411bbbf753 |
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| cites | cdi_FETCH-LOGICAL-c2020-58329d11bd1da39867b43ae13bcf97e721733080c3ef0b0d68eb20d411bbbf753 |
| container_end_page | 16776 |
| container_issue | 52 |
| container_start_page | 16773 |
| container_title | Angewandte Chemie |
| container_volume | 129 |
| creator | Kleijn, Laurens H. J. Vlieg, Hedwich C. Wood, Thomas M. Sastre Toraño, Javier Janssen, Bert J. C. Martin, Nathaniel I. |
| description | The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.
Die Kristallstruktur des Calcium‐abhängigen Antibiotikums (CDA) Laspartomycin C im Komplex mit seinem bakteriellen Angriffsziel Undecaprenylphosphat (C55‐P) ist das erste Beispiel für einen entsprechenden Calcium enthaltenden CDA‐Komplex. Anders als klinisch eingesetzte Antibiotika tötet Laspartomycin C Bakterien, indem es an C55‐P bindet und die Peptidoglykan‐Biosynthese blockiert. Die vorgestellte Struktur illustriert diese Wechselwirkung. |
| doi_str_mv | 10.1002/ange.201709240 |
| format | article |
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Die Kristallstruktur des Calcium‐abhängigen Antibiotikums (CDA) Laspartomycin C im Komplex mit seinem bakteriellen Angriffsziel Undecaprenylphosphat (C55‐P) ist das erste Beispiel für einen entsprechenden Calcium enthaltenden CDA‐Komplex. Anders als klinisch eingesetzte Antibiotika tötet Laspartomycin C Bakterien, indem es an C55‐P bindet und die Peptidoglykan‐Biosynthese blockiert. Die vorgestellte Struktur illustriert diese Wechselwirkung.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.201709240</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Antibiotics ; Bacteria ; Bakterienzellwand ; C55-P ; Calcium ; Calcium-abhängige Antibiotika ; Chemistry ; Crystal structure ; Kristallstrukturen ; Laspartomycin C ; Molecular structure ; Phospholipids ; Target recognition</subject><ispartof>Angewandte Chemie, 2017-12, Vol.129 (52), p.16773-16776</ispartof><rights>2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.</rights><rights>2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2020-58329d11bd1da39867b43ae13bcf97e721733080c3ef0b0d68eb20d411bbbf753</citedby><cites>FETCH-LOGICAL-c2020-58329d11bd1da39867b43ae13bcf97e721733080c3ef0b0d68eb20d411bbbf753</cites><orcidid>0000-0001-8246-3006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kleijn, Laurens H. J.</creatorcontrib><creatorcontrib>Vlieg, Hedwich C.</creatorcontrib><creatorcontrib>Wood, Thomas M.</creatorcontrib><creatorcontrib>Sastre Toraño, Javier</creatorcontrib><creatorcontrib>Janssen, Bert J. C.</creatorcontrib><creatorcontrib>Martin, Nathaniel I.</creatorcontrib><title>A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C</title><title>Angewandte Chemie</title><description>The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.
Die Kristallstruktur des Calcium‐abhängigen Antibiotikums (CDA) Laspartomycin C im Komplex mit seinem bakteriellen Angriffsziel Undecaprenylphosphat (C55‐P) ist das erste Beispiel für einen entsprechenden Calcium enthaltenden CDA‐Komplex. Anders als klinisch eingesetzte Antibiotika tötet Laspartomycin C Bakterien, indem es an C55‐P bindet und die Peptidoglykan‐Biosynthese blockiert. Die vorgestellte Struktur illustriert diese Wechselwirkung.</description><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bakterienzellwand</subject><subject>C55-P</subject><subject>Calcium</subject><subject>Calcium-abhängige Antibiotika</subject><subject>Chemistry</subject><subject>Crystal structure</subject><subject>Kristallstrukturen</subject><subject>Laspartomycin C</subject><subject>Molecular structure</subject><subject>Phospholipids</subject><subject>Target recognition</subject><issn>0044-8249</issn><issn>1521-3757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkb1u2zAUhYmiBeomXTsT6CznkpRNcTSUNAngJkB-ZoGkrhwGsqiSVAJtWbr3CfJweZLKcZGMnS5w8X3nDIeQbwzmDIAf6W6Dcw5MguI5fCAztuAsE3IhP5IZQJ5nBc_VZ_IlxnsAWHKpZuR5Rc_c5u7l6c8VRt8OyfmOlmGMSbf0OoXBpiEgTXc60St8QN1G-tO3aIdWB3qMSbvp4xt6o8MGd4z1m869xphx8pCWurVu2E4Vx9hjV2OX6Nr1vsc-uRrpqkvOOJ-cpWsdex2S347WdS9Pv8tD8qmZKvHrv3tAbn-c3JRn2fry9LxcrTPLgUO2KARXNWOmZrUWqlhKkwuNTBjbKImSMykEFGAFNmCgXhZoONT5ZBjTyIU4IN_3uX3wvwaMqbr3Q-imyoopWXBQINhEzfeUDT7GgE3VB7fVYawYVLsNqt0G1dsGk6D2wqNrcfwPXa0uTk_e3b_Id5C4</recordid><startdate>20171222</startdate><enddate>20171222</enddate><creator>Kleijn, Laurens H. 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C.</au><au>Martin, Nathaniel I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C</atitle><jtitle>Angewandte Chemie</jtitle><date>2017-12-22</date><risdate>2017</risdate><volume>129</volume><issue>52</issue><spage>16773</spage><epage>16776</epage><pages>16773-16776</pages><issn>0044-8249</issn><eissn>1521-3757</eissn><abstract>The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.
Die Kristallstruktur des Calcium‐abhängigen Antibiotikums (CDA) Laspartomycin C im Komplex mit seinem bakteriellen Angriffsziel Undecaprenylphosphat (C55‐P) ist das erste Beispiel für einen entsprechenden Calcium enthaltenden CDA‐Komplex. Anders als klinisch eingesetzte Antibiotika tötet Laspartomycin C Bakterien, indem es an C55‐P bindet und die Peptidoglykan‐Biosynthese blockiert. Die vorgestellte Struktur illustriert diese Wechselwirkung.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ange.201709240</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-8246-3006</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Angewandte Chemie, 2017-12, Vol.129 (52), p.16773-16776 |
| issn | 0044-8249 1521-3757 |
| language | eng |
| recordid | cdi_proquest_journals_1978209031 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Antibiotics Bacteria Bakterienzellwand C55-P Calcium Calcium-abhängige Antibiotika Chemistry Crystal structure Kristallstrukturen Laspartomycin C Molecular structure Phospholipids Target recognition |
| title | A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C |
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