A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

• Published in: Applied organometallic chemistry 2018-01, Vol.32 (1), p.n/a
• Main Authors: Al Zoubi, Wail, Al‐Hamdani, Abbas Ali Salih, Ahmed, Susan Duraid, Ko, Young Gun
• Format: Article
• Language: English
• Subjects: antibacterial activity; Bacteria; Benzoic acid; Biological activity; Chemical synthesis; Chemistry; Cobalt; E coli; Fourier transforms; Gram-positive bacteria; Imines; Infrared radiation; Ligands; Magnetic moments; Nickel; NMR; Nuclear magnetic resonance; Palladium; Platinum; spectral studies; theoretical studies; thermodynamic
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.3895

A new Azo‐Schiff base ligand L was prepared by reaction of m‐hydroxy benzoic acid with (Schiff base B) of 3‐[2‐(1H–indol‐3‐yl)‐ethylimino]‐1.5‐dimethyl‐2‐phenyl‐2,3‐dihydro‐1H‐pyrazol‐4‐ylamine. This synthesized ligand was used for complexation with different metal ions like Ni(II), Co(II), Pd(II) and Pt(IV) by using a molar ratio of ligand: metal as 1:1. Resulted compounds were characterized by NMR (1H and 13C), UV–vis spectroscopy, TGA, FT‐IR, MS, elemental analysis, magnetic moment and molar conductivity studies. The activation thermodynamic parameters, such as ΔE*, ΔH*, ΔS*, ΔG*and K are calculated from the TGA curves using Coats‐Redfern method. Hyper Chem‐8 program has been used to predict structural geometries of compounds in gas phase. The biological activities of Schiff base and its complexes had been tested in vitro against, two Gram positive bacteria (Bacillus subtillis and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruguinosa). Prepared ligand was used for complexation with different metal cations like Ni(II), Co(II), Pd(II) and Pt(IV) by using a molar ratio of ligand: metal as 1:1. These complexes were characterized by NMR (1H and 13C), UV–vis spectroscopy, TGA, FT‐IR, MS, elemental analysis, magnetic moment and molar conductivity studies. Biological activities of Schiff base complexes had been tested in vitro against, two Gram positive bacteria (Bacillus subtillis and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruguinosa).