A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction

. Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarc...

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Bibliographic Details
Published in:Journal of internal medicine 2000-10, Vol.248 (4), p.316-318
Main Authors: Lip, G. Y. H., Lydakis, C., Nuttall, S. L., Landray, M. J., Watson, R. D. S., Blann, A. D.
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Biological and medical sciences
Cardiology. Vascular system
Case-Control Studies
Coronary heart disease
endothelial damage
Endothelium, Vascular - drug effects
Female
Fibrinogen - drug effects
Fibrinogen - metabolism
Fibrinolytic Agents - adverse effects
Heart
Humans
Male
Medical sciences
Middle Aged
myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - drug therapy
Oxidative Stress - drug effects
P-Selectin - blood
P-Selectin - drug effects
Pilot Projects
Platelet Activation - drug effects
platelets
Prospective Studies
Streptokinase - adverse effects
thrombolysis
Thrombomodulin - blood
Thrombomodulin - drug effects
Vitamin E
Vitamin E - blood
von Willebrand Factor - drug effects
von Willebrand Factor - metabolism
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Summary:. Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction. J Intern Med248: 316–318. Objective. To relate the changes in serum vitamin E, an essential antioxidant, to changes in fibrinogen, as well as indices of endothelial damage [as indicated by plasma markers, soluble thrombomodulin (sTM) and von Willebrand factor (vWf)], and an index of platelet activation [soluble P selectin (sPsel)], in myocardial infarction treated with thrombolytic therapy. Design and Setting. Prospective longitudinal pilot study in a teaching hospital Coronary Care Unit. Subjects and intervention. Seventeen patients (12 men; mean age 62 years ± SD 11 years) admitted with acute myocardial infarction (AMI), who were given thrombolytic therapy, and 59 healthy controls. Results. Baseline levels of fibrinogen (Mann–Whitney test, P = 0.0055) and vWf (P 
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.2000.00738.x