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A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction
. Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarc...
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| Published in: | Journal of internal medicine 2000-10, Vol.248 (4), p.316-318 |
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| container_title | Journal of internal medicine |
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| creator | Lip, G. Y. H. Lydakis, C. Nuttall, S. L. Landray, M. J. Watson, R. D. S. Blann, A. D. |
| description | . Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction. J Intern Med248: 316–318.
Objective. To relate the changes in serum vitamin E, an essential antioxidant, to changes in fibrinogen, as well as indices of endothelial damage [as indicated by plasma markers, soluble thrombomodulin (sTM) and von Willebrand factor (vWf)], and an index of platelet activation [soluble P selectin (sPsel)], in myocardial infarction treated with thrombolytic therapy.
Design and Setting. Prospective longitudinal pilot study in a teaching hospital Coronary Care Unit.
Subjects and intervention. Seventeen patients (12 men; mean age 62 years ± SD 11 years) admitted with acute myocardial infarction (AMI), who were given thrombolytic therapy, and 59 healthy controls.
Results. Baseline levels of fibrinogen (Mann–Whitney test, P = 0.0055) and vWf (P |
| doi_str_mv | 10.1046/j.1365-2796.2000.00738.x |
| format | article |
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Objective. To relate the changes in serum vitamin E, an essential antioxidant, to changes in fibrinogen, as well as indices of endothelial damage [as indicated by plasma markers, soluble thrombomodulin (sTM) and von Willebrand factor (vWf)], and an index of platelet activation [soluble P selectin (sPsel)], in myocardial infarction treated with thrombolytic therapy.
Design and Setting. Prospective longitudinal pilot study in a teaching hospital Coronary Care Unit.
Subjects and intervention. Seventeen patients (12 men; mean age 62 years ± SD 11 years) admitted with acute myocardial infarction (AMI), who were given thrombolytic therapy, and 59 healthy controls.
Results. Baseline levels of fibrinogen (Mann–Whitney test, P = 0.0055) and vWf (P < 0.001) were significantly higher than controls, but sPsel, sTM or vitamin E levels were not significantly different. Following thrombolysis, as expected, median concentrations of plasma fibrinogen fell profoundly (Friedman
anovaP < 0.001) so that after 45 min, levels were undetectable in 13 patients. At 24‐h median fibrinogen concentration had recovered to approximately 30% of baseline (P < 0.01) and was still undetectable in three patients. Levels of vWf and sPsel increased steadily, reaching significance after three hours (both P < 0.05). However, levels of sTM rose immediately after thrombolysis, peaking between 1 and 3 h, and remained elevated at 24 h. These increases corresponded to a simultaneous early fall in serum vitamin E concentrations.
Conclusion. The present pilot study demonstrates significant endothelial damage and platelet activation in association with increased oxidative stress following streptokinase therapy for AMI.</description><identifier>ISSN: 0954-6820</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1046/j.1365-2796.2000.00738.x</identifier><identifier>PMID: 11086642</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Analysis of Variance ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Coronary heart disease ; endothelial damage ; Endothelium, Vascular - drug effects ; Female ; Fibrinogen - drug effects ; Fibrinogen - metabolism ; Fibrinolytic Agents - adverse effects ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - drug therapy ; Oxidative Stress - drug effects ; P-Selectin - blood ; P-Selectin - drug effects ; Pilot Projects ; Platelet Activation - drug effects ; platelets ; Prospective Studies ; Streptokinase - adverse effects ; thrombolysis ; Thrombomodulin - blood ; Thrombomodulin - drug effects ; Vitamin E ; Vitamin E - blood ; von Willebrand Factor - drug effects ; von Willebrand Factor - metabolism</subject><ispartof>Journal of internal medicine, 2000-10, Vol.248 (4), p.316-318</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Oct 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4718-6a159c49d660654771fcdda622461c54d8b14df5b6447a419db211f3014b04633</citedby><cites>FETCH-LOGICAL-c4718-6a159c49d660654771fcdda622461c54d8b14df5b6447a419db211f3014b04633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1497544$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11086642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lip, G. Y. H.</creatorcontrib><creatorcontrib>Lydakis, C.</creatorcontrib><creatorcontrib>Nuttall, S. L.</creatorcontrib><creatorcontrib>Landray, M. J.</creatorcontrib><creatorcontrib>Watson, R. D. S.</creatorcontrib><creatorcontrib>Blann, A. D.</creatorcontrib><title>A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>. Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction. J Intern Med248: 316–318.
Objective. To relate the changes in serum vitamin E, an essential antioxidant, to changes in fibrinogen, as well as indices of endothelial damage [as indicated by plasma markers, soluble thrombomodulin (sTM) and von Willebrand factor (vWf)], and an index of platelet activation [soluble P selectin (sPsel)], in myocardial infarction treated with thrombolytic therapy.
Design and Setting. Prospective longitudinal pilot study in a teaching hospital Coronary Care Unit.
Subjects and intervention. Seventeen patients (12 men; mean age 62 years ± SD 11 years) admitted with acute myocardial infarction (AMI), who were given thrombolytic therapy, and 59 healthy controls.
Results. Baseline levels of fibrinogen (Mann–Whitney test, P = 0.0055) and vWf (P < 0.001) were significantly higher than controls, but sPsel, sTM or vitamin E levels were not significantly different. Following thrombolysis, as expected, median concentrations of plasma fibrinogen fell profoundly (Friedman
anovaP < 0.001) so that after 45 min, levels were undetectable in 13 patients. At 24‐h median fibrinogen concentration had recovered to approximately 30% of baseline (P < 0.01) and was still undetectable in three patients. Levels of vWf and sPsel increased steadily, reaching significance after three hours (both P < 0.05). However, levels of sTM rose immediately after thrombolysis, peaking between 1 and 3 h, and remained elevated at 24 h. These increases corresponded to a simultaneous early fall in serum vitamin E concentrations.
Conclusion. The present pilot study demonstrates significant endothelial damage and platelet activation in association with increased oxidative stress following streptokinase therapy for AMI.</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Coronary heart disease</subject><subject>endothelial damage</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Female</subject><subject>Fibrinogen - drug effects</subject><subject>Fibrinogen - metabolism</subject><subject>Fibrinolytic Agents - adverse effects</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Oxidative Stress - drug effects</subject><subject>P-Selectin - blood</subject><subject>P-Selectin - drug effects</subject><subject>Pilot Projects</subject><subject>Platelet Activation - drug effects</subject><subject>platelets</subject><subject>Prospective Studies</subject><subject>Streptokinase - adverse effects</subject><subject>thrombolysis</subject><subject>Thrombomodulin - blood</subject><subject>Thrombomodulin - drug effects</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><subject>von Willebrand Factor - drug effects</subject><subject>von Willebrand Factor - metabolism</subject><issn>0954-6820</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqNkMtu1TAQhi1ERQ-FV0AWYptgJ7aTLFhUFZeiVt3A2nJ8AQcfO9gObXY8As_Ik-BwjtptVzOa-f4Z6QMAYlRjRNjbqcYto1XTDaxuEEI1Ql3b13dPwO5-8RTs0EBJxfoGnYLnKU0I4RYx9AycYox6xkizA-s5nK0LGaa8qBUGU5qo5xx-WC-S_vv7j_VqkVpB7VXI37WzwkHrpyWuUHgFZyeydjpDIbP9JbINHprgXLi1_lsZLlnD_RqkiOqQNCLKjXoBToxwSb881jPw9cP7Lxefqqubj5cX51eVJB3uKyYwHSQZFGOIUdJ12EilBGsawrCkRPUjJsrQkRHSCYIHNTYYmxZhMhZVbXsGXh_uzjH8XHTKfApL9OUlx0M30Ib0tED9AZIxpBS14XO0exFXjhHflPOJb2b5ZpZvyvl_5fyuRF8d7y_jXquH4NFxAd4cAZGkcCYKL2164MjQUUIK9u6A3Vqn10f_559vLq9L1_4DgB-e6g</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Lip, G. Y. H.</creator><creator>Lydakis, C.</creator><creator>Nuttall, S. L.</creator><creator>Landray, M. J.</creator><creator>Watson, R. D. S.</creator><creator>Blann, A. D.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope></search><sort><creationdate>200010</creationdate><title>A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction</title><author>Lip, G. Y. H. ; Lydakis, C. ; Nuttall, S. L. ; Landray, M. J. ; Watson, R. D. S. ; Blann, A. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4718-6a159c49d660654771fcdda622461c54d8b14df5b6447a419db211f3014b04633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Coronary heart disease</topic><topic>endothelial damage</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Female</topic><topic>Fibrinogen - drug effects</topic><topic>Fibrinogen - metabolism</topic><topic>Fibrinolytic Agents - adverse effects</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Oxidative Stress - drug effects</topic><topic>P-Selectin - blood</topic><topic>P-Selectin - drug effects</topic><topic>Pilot Projects</topic><topic>Platelet Activation - drug effects</topic><topic>platelets</topic><topic>Prospective Studies</topic><topic>Streptokinase - adverse effects</topic><topic>thrombolysis</topic><topic>Thrombomodulin - blood</topic><topic>Thrombomodulin - drug effects</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><topic>von Willebrand Factor - drug effects</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lip, G. Y. H.</creatorcontrib><creatorcontrib>Lydakis, C.</creatorcontrib><creatorcontrib>Nuttall, S. L.</creatorcontrib><creatorcontrib>Landray, M. J.</creatorcontrib><creatorcontrib>Watson, R. D. S.</creatorcontrib><creatorcontrib>Blann, A. D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lip, G. Y. H.</au><au>Lydakis, C.</au><au>Nuttall, S. L.</au><au>Landray, M. J.</au><au>Watson, R. D. S.</au><au>Blann, A. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2000-10</date><risdate>2000</risdate><volume>248</volume><issue>4</issue><spage>316</spage><epage>318</epage><pages>316-318</pages><issn>0954-6820</issn><eissn>1365-2796</eissn><abstract>. Lip GYH, Lydakis C, Nuttall SL, Landray MJ, Watson RDS, Blann AD (Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK). A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction. J Intern Med248: 316–318.
Objective. To relate the changes in serum vitamin E, an essential antioxidant, to changes in fibrinogen, as well as indices of endothelial damage [as indicated by plasma markers, soluble thrombomodulin (sTM) and von Willebrand factor (vWf)], and an index of platelet activation [soluble P selectin (sPsel)], in myocardial infarction treated with thrombolytic therapy.
Design and Setting. Prospective longitudinal pilot study in a teaching hospital Coronary Care Unit.
Subjects and intervention. Seventeen patients (12 men; mean age 62 years ± SD 11 years) admitted with acute myocardial infarction (AMI), who were given thrombolytic therapy, and 59 healthy controls.
Results. Baseline levels of fibrinogen (Mann–Whitney test, P = 0.0055) and vWf (P < 0.001) were significantly higher than controls, but sPsel, sTM or vitamin E levels were not significantly different. Following thrombolysis, as expected, median concentrations of plasma fibrinogen fell profoundly (Friedman
anovaP < 0.001) so that after 45 min, levels were undetectable in 13 patients. At 24‐h median fibrinogen concentration had recovered to approximately 30% of baseline (P < 0.01) and was still undetectable in three patients. Levels of vWf and sPsel increased steadily, reaching significance after three hours (both P < 0.05). However, levels of sTM rose immediately after thrombolysis, peaking between 1 and 3 h, and remained elevated at 24 h. These increases corresponded to a simultaneous early fall in serum vitamin E concentrations.
Conclusion. The present pilot study demonstrates significant endothelial damage and platelet activation in association with increased oxidative stress following streptokinase therapy for AMI.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11086642</pmid><doi>10.1046/j.1365-2796.2000.00738.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Analysis of Variance Biological and medical sciences Cardiology. Vascular system Case-Control Studies Coronary heart disease endothelial damage Endothelium, Vascular - drug effects Female Fibrinogen - drug effects Fibrinogen - metabolism Fibrinolytic Agents - adverse effects Heart Humans Male Medical sciences Middle Aged myocardial infarction Myocardial Infarction - blood Myocardial Infarction - drug therapy Oxidative Stress - drug effects P-Selectin - blood P-Selectin - drug effects Pilot Projects Platelet Activation - drug effects platelets Prospective Studies Streptokinase - adverse effects thrombolysis Thrombomodulin - blood Thrombomodulin - drug effects Vitamin E Vitamin E - blood von Willebrand Factor - drug effects von Willebrand Factor - metabolism |
| title | A pilot study of streptokinase‐induced endothelial injury and platelet activation following acute myocardial infarction |
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