Tunability of polycaprolactone hydrophilicity by carboxymethyl cellulose loading

ABSTRACT Carboxymethyl cellulose (CMC) is herein proposed as additive in polycaprolactone (PCL) matrices to obtain composites with tunable hydrophilicity. This composite material can be obtained by compression molding. The thermogravimetric degradation profile, the FTIR spectra, values of the water...

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Bibliographic Details
Published in:Journal of applied polymer science 2018-04, Vol.135 (14), p.n/a
Main Authors: Alemán‐Domínguez, M. E., Ortega, Z., Benítez, A. N., Vilariño‐Feltrer, G., Gómez‐Tejedor, J. A., Vallés‐Lluch, A.
Format: Article
Language:English
Subjects:
Biocompatibility
Biological effects
biomedical applications
Biomedical materials
Carboxymethyl cellulose
Cellulose
Composite materials
Contact angle
Degradation
Hydrophilicity
Materials science
Polycaprolactone
Polymers
polysaccharides
Pressure molding
swelling
thermogravimetric analysis (TGA)
thermoplastics
Toxicity
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Summary:ABSTRACT Carboxymethyl cellulose (CMC) is herein proposed as additive in polycaprolactone (PCL) matrices to obtain composites with tunable hydrophilicity. This composite material can be obtained by compression molding. The thermogravimetric degradation profile, the FTIR spectra, values of the water contact angle (WCA), water and phosphate‐buffered saline uptake values, and the results of a cytotoxicity assessment are presented herein. The concentrations of CMC in the groups of samples are 0, 2, 5, 10, and 20%. The WCA on the prewetted state decreases proportionally to the concentration of the additive. These results evidence the possibility of obtaining a PCL‐based composite with tunable hydrophilicity. Besides, the biological assessment does not reveal any cytotoxic effects. Therefore, the addition of CMC entails an innovative strategy to control the water affinity of PCL in biomedical applications where such feature is required to improve diffusion of biological medium through, or accelerate degradation by hydrolysis. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46134. Carboxymethyl cellulose loading can be used as a strategy to increase the hydrophilicity of polycaprolactone matrices. It is possible to tailor the water affinity of the matrix by modifying the content of this additive. Besides, the composites do not show a cytotoxic effect, so they are promising for biomedical applications.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.46134