Rivastigmine in Wernicke-Korsakoff's syndrome: Five patients with rivastigmine showed no more improvement than five patients without rivastigmine

Aims: To evaluate whether rivastigmine, an achetylcholinesterase inhibitor (AChEl), may be effective in restoring memory in Wernicke-Korsakoff's syndrome (WKS). Methods: Five patients treated with rivastigmine for a period of 6 months were compared with five matched control patients, who receiv...

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Published in:Alcohol and alcoholism (Oxford) 2008-01, Vol.43 (1), p.70-72
Main Authors: Luykx, Han J., Dorresteijn, Lucille D. A., Haffmans, P. M. Judith, Bonebakker, Annette, Kerkmeer, Margreet, Hendriks, Vincent M.
Format: Article
Language:English
Subjects:
Adult
Alcohol Drinking - drug therapy
Alcohol Drinking - psychology
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Drug Administration Schedule
Humans
Korsakoff Syndrome - complications
Korsakoff Syndrome - drug therapy
Korsakoff Syndrome - psychology
Male
Medical sciences
Memory Disorders - complications
Memory Disorders - drug therapy
Memory Disorders - psychology
Middle Aged
Neuroprotective Agents - therapeutic use
Phenylcarbamates - therapeutic use
Rivastigmine
Toxicology
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Summary:Aims: To evaluate whether rivastigmine, an achetylcholinesterase inhibitor (AChEl), may be effective in restoring memory in Wernicke-Korsakoff's syndrome (WKS). Methods: Five patients treated with rivastigmine for a period of 6 months were compared with five matched control patients, who received 6 months' conventional treatment, but without rivastigmine. Memory tests were administered at baseline and after 6 months. Results: Slight improvements were observed in both rivastigmine and control patients, but no significant differences in improvements were found between the study groups. Conclusion: Treatment with rivastigmine may not be effective in restoring memory in WKS patients.
ISSN:0735-0414
1464-3502
DOI:10.1093/alcalc/agm158