Analysis of mitochondria, endoplasmic reticulum and actin filaments after PDT with AlPcS4

Photodynamic therapy (PDT) is a therapeutic modality for the treatment of tumors. This technique uses a visible light to activate a photosensitizer compounds, leading to a photo-oxidation process of biological tissue that can induce apoptosis or necrosis both in vivo and in vitro. However many of th...

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Bibliographic Details
Published in:Lasers in medical science 2004-03, Vol.18 (4), p.207
Main Authors: S. D. R. M. Ferreira, Tedesco, A C, Sousa, G, Zângaro, R A, Silva, N S, Pacheco, M T T, Pacheco-Soares, C
Format: Article
Language:English
Online Access:Get full text
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Summary:Photodynamic therapy (PDT) is a therapeutic modality for the treatment of tumors. This technique uses a visible light to activate a photosensitizer compounds, leading to a photo-oxidation process of biological tissue that can induce apoptosis or necrosis both in vivo and in vitro. However many of the cytotoxic effects remain an open question to be investigated. The cytotoxicity to specific cellular targets of classical photosensitizers used in the PDT in vitro has been analyzed in this work. The photosensitizing effects of Chloroaluminum Phthalocyanine Tetrasulfonate (AlPcS
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-003-0282-6