Complete pathologic response after preoperative rectal cancer chemoradiotherapy

Background:  Following preoperative treatment of rectal cancer with chemoradiotherapy (CRT), a complete pathological response (CPR) can be seen in the surgical specimen. The aim of this study was to assess the outcome of these patients as compared with those who did not have a complete response. Met...

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Bibliographic Details
Published in:ANZ journal of surgery 2009-06, Vol.79 (6), p.481-484
Main Authors: Ciccocioppo, Anthony, Stephens, Jacqueline H., Hewett, Peter J., Rieger, Nicholas A.
Format: Article
Language:English
Subjects:
adjuvant chemotherapy
adjuvant radiotherapy
Aged
Antimetabolites, Antineoplastic - therapeutic use
Chemotherapy
Chemotherapy, Adjuvant
Clinical outcomes
Colorectal cancer
Combined Modality Therapy
Comparative studies
Disease-Free Survival
Female
Fluorouracil - therapeutic use
Follow-Up Studies
Humans
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Radiation therapy
Radiotherapy Dosage
Radiotherapy, Adjuvant
rectal neoplasm
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Recurrence
Retrospective Studies
Surgery
survival rate
Tomography, X-Ray Computed
Treatment Outcome
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Summary:Background:  Following preoperative treatment of rectal cancer with chemoradiotherapy (CRT), a complete pathological response (CPR) can be seen in the surgical specimen. The aim of this study was to assess the outcome of these patients as compared with those who did not have a complete response. Methods:  A retrospective study of the outcome of patients managed with preoperative CRT for their rectal cancer was conducted. Results:  Between November 1998 and July 2004, there were 530 new presentations of rectal cancer at The Queen Elizabeth and Royal Adelaide hospitals. Forty of these patients (7.5%) were treated with long‐course preoperative CRT. After resection, a CPR was seen in seven patients (17.5%). These patients were all disease free at January 2006 after a median follow‐up of 6.0 years (range 1.42–7.02 years). One patient had died from non‐tumour‐/surgery‐related causes. Tumour recurrence, but not mortality, in this group was superior to the comparison group of patients without a CPR. Conclusions:  None of our patients who had a CPR after preoperative CRT have recurred or died from their disease.
ISSN:1445-1433
1445-2197
DOI:10.1111/j.1445-2197.2009.04950.x