Regulation of the CaV3.2 calcium channels in health and disease

Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies...

Full description

Saved in:
Bibliographic Details
Published in:EUROPEAN PHARMACEUTICAL JOURNAL 2017-11, Vol.64 (2), p.15
Main Author: Lacinová, Ľ
Format: Article
Language:English
Subjects:
Calcium
Disease
Health
Pathology
Tissues
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 2
container_start_page 15
container_title EUROPEAN PHARMACEUTICAL JOURNAL
container_volume 64
creator Lacinová, Ľ
description Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.
doi_str_mv 10.1515/afpuc-2017-0019
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1982837225</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1982837225</sourcerecordid><originalsourceid>FETCH-LOGICAL-p98t-caf6329096cce54d772832d731485ca39b8004ba6836d3fd3af7697155b6cc0b3</originalsourceid><addsrcrecordid>eNotjTtrwzAYAEWhkJBm7irorFTSZ72mUkwfgUChhK7hsx6xgyu7kf3_a2inm-6OkHvBd0IJ9YhpnD2TXBjGuXA3ZC0rBUwbqVZkW8qFcy6t0k6YNXn6jOe5x6kbMh0SndpIa_yCnaQee9_N39S3mHPsC-0ybSP2U0sxBxq6ErHEO3KbsC9x-88NOb6-HOt3dvh429fPBzY6OzGPSYN03Gnvo6qCMdKCDAZEZZVHcI3lvGpQW9ABUgBMRjsjlGoWgzewIQ9_2fE6_MyxTKfLMF_zcjwJZ5eYkVLBL64_SIA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1982837225</pqid></control><display><type>article</type><title>Regulation of the CaV3.2 calcium channels in health and disease</title><source>Publicly Available Content Database</source><creator>Lacinová, Ľ</creator><creatorcontrib>Lacinová, Ľ</creatorcontrib><description>Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.</description><identifier>EISSN: 2453-6725</identifier><identifier>DOI: 10.1515/afpuc-2017-0019</identifier><language>eng</language><publisher>Warsaw: De Gruyter Poland</publisher><subject>Calcium ; Disease ; Health ; Pathology ; Tissues</subject><ispartof>EUROPEAN PHARMACEUTICAL JOURNAL, 2017-11, Vol.64 (2), p.15</ispartof><rights>Copyright De Gruyter Open Sp. z o.o. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1982837225?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590</link.rule.ids></links><search><creatorcontrib>Lacinová, Ľ</creatorcontrib><title>Regulation of the CaV3.2 calcium channels in health and disease</title><title>EUROPEAN PHARMACEUTICAL JOURNAL</title><description>Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.</description><subject>Calcium</subject><subject>Disease</subject><subject>Health</subject><subject>Pathology</subject><subject>Tissues</subject><issn>2453-6725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNotjTtrwzAYAEWhkJBm7irorFTSZ72mUkwfgUChhK7hsx6xgyu7kf3_a2inm-6OkHvBd0IJ9YhpnD2TXBjGuXA3ZC0rBUwbqVZkW8qFcy6t0k6YNXn6jOe5x6kbMh0SndpIa_yCnaQee9_N39S3mHPsC-0ybSP2U0sxBxq6ErHEO3KbsC9x-88NOb6-HOt3dvh429fPBzY6OzGPSYN03Gnvo6qCMdKCDAZEZZVHcI3lvGpQW9ABUgBMRjsjlGoWgzewIQ9_2fE6_MyxTKfLMF_zcjwJZ5eYkVLBL64_SIA</recordid><startdate>20171127</startdate><enddate>20171127</enddate><creator>Lacinová, Ľ</creator><general>De Gruyter Poland</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20171127</creationdate><title>Regulation of the CaV3.2 calcium channels in health and disease</title><author>Lacinová, Ľ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p98t-caf6329096cce54d772832d731485ca39b8004ba6836d3fd3af7697155b6cc0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Calcium</topic><topic>Disease</topic><topic>Health</topic><topic>Pathology</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lacinová, Ľ</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>EUROPEAN PHARMACEUTICAL JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lacinová, Ľ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of the CaV3.2 calcium channels in health and disease</atitle><jtitle>EUROPEAN PHARMACEUTICAL JOURNAL</jtitle><date>2017-11-27</date><risdate>2017</risdate><volume>64</volume><issue>2</issue><spage>15</spage><pages>15-</pages><eissn>2453-6725</eissn><abstract>Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.</abstract><cop>Warsaw</cop><pub>De Gruyter Poland</pub><doi>10.1515/afpuc-2017-0019</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier EISSN: 2453-6725
ispartof EUROPEAN PHARMACEUTICAL JOURNAL, 2017-11, Vol.64 (2), p.15
issn 2453-6725
language eng
recordid cdi_proquest_journals_1982837225
source Publicly Available Content Database
subjects Calcium
Disease
Health
Pathology
Tissues
title Regulation of the CaV3.2 calcium channels in health and disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T00%3A17%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20the%20CaV3.2%20calcium%20channels%20in%20health%20and%20disease&rft.jtitle=EUROPEAN%20PHARMACEUTICAL%20JOURNAL&rft.au=Lacinov%C3%A1,%20%C4%BD&rft.date=2017-11-27&rft.volume=64&rft.issue=2&rft.spage=15&rft.pages=15-&rft.eissn=2453-6725&rft_id=info:doi/10.1515/afpuc-2017-0019&rft_dat=%3Cproquest%3E1982837225%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p98t-caf6329096cce54d772832d731485ca39b8004ba6836d3fd3af7697155b6cc0b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1982837225&rft_id=info:pmid/&rfr_iscdi=true