Alcohol intake and T cell aging in HIV+ humans are associated with gut bacterial burden

Preclinical and clinical studies suggest that chronic alcohol consumption leads to gastrointestinal inflammation, in part, via alcohol-associated bacterial overgrowth and microbiota acetaldehyde production. TLFB total alcohol consumption (g) and AIT (cells/μL) were positively associated with stool 1...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2018-02, Vol.66, p.92-92
Main Authors: Maffei, V.J., Siggins, R.W., Luo, M., Molina, P., Taylor, C.M., Welsh, D.A.
Format: Article
Language:English
Subjects:
Aging
Alcohol use
Alcoholic beverages
Alcohols
Bacteria
HIV
Human immunodeficiency virus
Lymphocytes
Lymphocytes T
Microbiota
Production capacity
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Summary:Preclinical and clinical studies suggest that chronic alcohol consumption leads to gastrointestinal inflammation, in part, via alcohol-associated bacterial overgrowth and microbiota acetaldehyde production. TLFB total alcohol consumption (g) and AIT (cells/μL) were positively associated with stool 16S gene copy count (p = 0.04 & p = 0.04, respectively) after correction for clinical (age, BMI, sex, ART-compliance & CD4-count) and technical (homogenization batch & sequencing depth) confounding factors. [...]TLFB and AIT were positively associated with inferred KatG gene abundance (p = 0.04 & p = 0.03, respectively) after scaling KatG gene abundance by 16S gene copy count.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2017.11.020