CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population

Oxidative stress is believed to play an important role in the pathogenesis of considerable number of complex diseases. The antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) are important components of cell defense against oxidative stress, and polymorphisms in the genes which regul...

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Bibliographic Details
Published in:Molecular biology reports 2010, Vol.37 (1), p.87-92
Main Authors: Suzen, H. Sinan, Gucyener, Emel, Sakalli, Ozgul, Uckun, Zuhal, Kose, Gulcin, Ustel, Duygu, Duydu, Yalcin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Case-Control Studies
Catalase - genetics
Enzymes
Female
Gene Frequency - genetics
Genotype
Genotype & phenotype
Glutathione Peroxidase - genetics
Glutathione Peroxidase GPX1
Histology
Humans
Leucine - genetics
Life Sciences
Male
Middle Aged
Molecular biology
Morphology
Pathogenesis
Polymorphism
Polymorphism, Single Nucleotide - genetics
Proline - genetics
Turkey
Young Adult
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Summary:Oxidative stress is believed to play an important role in the pathogenesis of considerable number of complex diseases. The antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) are important components of cell defense against oxidative stress, and polymorphisms in the genes which regulate their expression may contribute to differences in susceptibility of individuals to oxidative damage caused by reactive oxygen species. The aim of this study was to assess the distribution of CAT C-262T and GPX1 Pro198Leu genotypic variants in a Turkish population. Genotyping analyses of CAT and GPX1 were conducted in 250 unrelated, healthy volunteers by the PCR-RFLP assay. The allele frequencies were 0.784 (C) and 0.216 (T) for CAT and 0.636 (C) and 0.364 (T) for GPX1 Pro198Leu. The genotype frequencies were 0.632 (CC), 0.304 (CT), and 0.064 (TT) for CAT and 0.416 (CC), 0.44 (CT), and 0.144 (TT) for GPX1 Pro198Leu. The genotype frequencies did not deviate from Hardy-Weinberg equilibrium. The results are compared with those of other reported populations. They showed marked ethnic group differences.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-009-9540-4