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A Review of Safety and Hazards Associated With the Artificial Pancreas
The artificial pancreas (AP) is a closed-loop device with the potential to reduce the complications associated with type 1 diabetes mellitus by maintaining euglycemia in patients. The AP encompasses an algorithm that determines the amount of insulin (and other hormones) to be administered to the pat...
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Published in: | IEEE reviews in biomedical engineering 2017, Vol.10, p.44-62 |
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creator | Ramkissoon, Charrise M. Aufderheide, Brian Bequette, B. Wayne Vehi, Josep |
description | The artificial pancreas (AP) is a closed-loop device with the potential to reduce the complications associated with type 1 diabetes mellitus by maintaining euglycemia in patients. The AP encompasses an algorithm that determines the amount of insulin (and other hormones) to be administered to the patient via a continuous subcutaneous insulin infusion pump using information provided by a continuous glucose monitor and other sensors. As the AP approaches commercialization, special attention must be given to safety within all the individual components, including physiological changes in the patient, as well as safety issues that can arise when these components are combined into a single system. Therefore, we analyzed the specific hazards applicable to the AP with the aim of exposing areas of safety that are yet to be addressed. |
doi_str_mv | 10.1109/RBME.2017.2749038 |
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Therefore, we analyzed the specific hazards applicable to the AP with the aim of exposing areas of safety that are yet to be addressed.</description><identifier>ISSN: 1937-3333</identifier><identifier>EISSN: 1941-1189</identifier><identifier>DOI: 10.1109/RBME.2017.2749038</identifier><identifier>PMID: 28880188</identifier><identifier>CODEN: IRBECO</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Artificial pancreas (AP) ; Biomedical measurement ; Biomedical monitoring ; Blood Glucose Self-Monitoring ; Commercialization ; Complications ; Diabetes ; Diabetes mellitus ; faults ; Glucagon - administration & dosage ; Glucose ; Guidelines as Topic ; Hazards ; Hormones ; Humans ; Injections, Subcutaneous ; Insulin ; Insulin Infusion Systems ; Pancreas ; Pancreas, Artificial - adverse effects ; Patient monitoring ; Safety ; type 1 diabetes</subject><ispartof>IEEE reviews in biomedical engineering, 2017, Vol.10, p.44-62</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. 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Therefore, we analyzed the specific hazards applicable to the AP with the aim of exposing areas of safety that are yet to be addressed.</description><subject>Artificial pancreas (AP)</subject><subject>Biomedical measurement</subject><subject>Biomedical monitoring</subject><subject>Blood Glucose Self-Monitoring</subject><subject>Commercialization</subject><subject>Complications</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>faults</subject><subject>Glucagon - administration & dosage</subject><subject>Glucose</subject><subject>Guidelines as Topic</subject><subject>Hazards</subject><subject>Hormones</subject><subject>Humans</subject><subject>Injections, Subcutaneous</subject><subject>Insulin</subject><subject>Insulin Infusion Systems</subject><subject>Pancreas</subject><subject>Pancreas, Artificial - adverse effects</subject><subject>Patient monitoring</subject><subject>Safety</subject><subject>type 1 diabetes</subject><issn>1937-3333</issn><issn>1941-1189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkE1PAjEQQBujEYL8AGNimnjxstiPbbc9IgExwWhQ43FTutOwBFhsdzX46y0BOTiXttM30-lD6JKSHqVE303vn4Y9RmjWY1mqCVcnqE11ShNKlT7d7XmW8Bgt1A1hQWKINKOKnKMWU0oRqlQbjfp4Cl8lfOPK4VfjoN5isy7w2PwYXwTcD6GypamhwB9lPcf1HHDf16UrY3aJX8zaejDhAp05swzQPawd9D4avg3GyeT54XHQnySWybRORDqbGaM1A6klxBPnzDpuCm2pMpljxFEwyhoQRKczm6qCC2aFFEBdRhjvoNt9342vPhsIdb4qg4Xl0qyhakIePy0lYyKTEb35hy6qxq_jdJFSqRCSSR4puqesr0Lw4PKNL1fGb3NK8p3nfOc533nOD55jzfWhczNbQXGs-LMagas9UALA8VoRFh8V_Bex9X8F</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Ramkissoon, Charrise M.</creator><creator>Aufderheide, Brian</creator><creator>Bequette, B. 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Wayne ; Vehi, Josep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c264t-54bbaa992e696e54b332cf3ad9c18a7f20f1ea8cae5094bc48d352c565e1f7023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Artificial pancreas (AP)</topic><topic>Biomedical measurement</topic><topic>Biomedical monitoring</topic><topic>Blood Glucose Self-Monitoring</topic><topic>Commercialization</topic><topic>Complications</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>faults</topic><topic>Glucagon - administration & dosage</topic><topic>Glucose</topic><topic>Guidelines as Topic</topic><topic>Hazards</topic><topic>Hormones</topic><topic>Humans</topic><topic>Injections, Subcutaneous</topic><topic>Insulin</topic><topic>Insulin Infusion Systems</topic><topic>Pancreas</topic><topic>Pancreas, Artificial - adverse effects</topic><topic>Patient monitoring</topic><topic>Safety</topic><topic>type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramkissoon, Charrise M.</creatorcontrib><creatorcontrib>Aufderheide, Brian</creatorcontrib><creatorcontrib>Bequette, B. 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As the AP approaches commercialization, special attention must be given to safety within all the individual components, including physiological changes in the patient, as well as safety issues that can arise when these components are combined into a single system. Therefore, we analyzed the specific hazards applicable to the AP with the aim of exposing areas of safety that are yet to be addressed.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>28880188</pmid><doi>10.1109/RBME.2017.2749038</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-2868-2918</orcidid><orcidid>https://orcid.org/0000-0001-6884-9789</orcidid></addata></record> |
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subjects | Artificial pancreas (AP) Biomedical measurement Biomedical monitoring Blood Glucose Self-Monitoring Commercialization Complications Diabetes Diabetes mellitus faults Glucagon - administration & dosage Glucose Guidelines as Topic Hazards Hormones Humans Injections, Subcutaneous Insulin Insulin Infusion Systems Pancreas Pancreas, Artificial - adverse effects Patient monitoring Safety type 1 diabetes |
title | A Review of Safety and Hazards Associated With the Artificial Pancreas |
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