Betulinic acid, natural pentacyclic triterpenoid prevents arsenic-induced nephrotoxicity in male Wistar rats

The aim of this study was to investigate the possible renoprotective role of betulinic acid, a natural pentacyclic triterpenoid on arsenic-induced nephrotoxicity. Male Wistar rats were divided into four groups and experiment was done as follows: normal control group, arsenic trioxide (4 mg/kg b.wt)...

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Published in:Comparative clinical pathology 2018, Vol.27 (1), p.37-44
Main Authors: Prakash, Binu, Surendran, Abhilash, Radhakrishnan Chandraprabha, Vineetha, Pettamanna, Arathi, Raveendran Nair, Harikumaran Nair
Format: Article
Language:English
Subjects:
Acids
Antifungal agents
Antioxidants
Arsenic
Arsenic trioxide
Betulinic acid
Catalase
Creatinine
Glutathione peroxidase
Glutathione transferase
Hematology
Kidneys
Lipid peroxidation
Medicine
Medicine & Public Health
Oncology
Original Article
Oxidative stress
Pathology
Rodents
Superoxide dismutase
Thiobarbituric acid
Urea
Uric acid
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Summary:The aim of this study was to investigate the possible renoprotective role of betulinic acid, a natural pentacyclic triterpenoid on arsenic-induced nephrotoxicity. Male Wistar rats were divided into four groups and experiment was done as follows: normal control group, arsenic trioxide (4 mg/kg b.wt) group, betulinic acid control (100 mg/kg b.wt) group, and a combination therapy group with both arsenic trioxide (4 mg/kg b.wt) and betulinic acid (100 mg/kg b.wt).The mode of administration of drugs was oral, and duration of study was 30 days. The results showed that the arsenic treatment inflated the urea, uric acid, creatinine, and serum γ-glutamyl tranferase (GGT) in serum and at the same time, creatinine clearance rate was down turned significantly ( p  
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-017-2548-6