Modulatory Effect of Aerobic Exercise Training on Doxorubicin-Induced Cardiotoxicity in Rats with Different Ages

We tested the hypothesis that aerobic exercise training (AET) would modulate doxorubicin-induced cardiotoxicity in rats of various ages. Wistar male rats ( n  = 72) were assigned to three groups (young, adult, and elderly) with three subgroups for each age: doxorubicin (DG, n  = 8), AET + doxorubici...

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Bibliographic Details
Published in:Cardiovascular toxicology 2018-02, Vol.18 (1), p.33-42
Main Authors: Ahmadian, Mehdi, Dabidi Roshan, Valiollah
Format: Article
Language:English
Subjects:
Aerobics
Age
Age Factors
Animal tissues
Animals
Antibiotics, Antineoplastic
Antioxidants
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
C-reactive protein
C-Reactive Protein - metabolism
Cancer
Cardiology
Cardiotoxicity
Chemotherapy
Disease Models, Animal
Doxorubicin
Exercise
Exercise Therapy
Fitness training programs
Geriatrics
Heart
Heart Diseases - chemically induced
Heart Diseases - metabolism
Heart Diseases - prevention & control
Heat shock proteins
HSP70 Heat-Shock Proteins - metabolism
Hsp70 protein
Interleukin 1
Interleukin 10
Interleukin-10 - metabolism
Interleukins
Male
Malondialdehyde
Malondialdehyde - metabolism
Myocardium - metabolism
Older people
Oxidative Stress
Pharmacology/Toxicology
Physical fitness
Rats
Rats, Wistar
Rodents
Subgroups
Superoxide
Superoxide dismutase
Superoxide Dismutase - metabolism
Toxicity
Training
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Summary:We tested the hypothesis that aerobic exercise training (AET) would modulate doxorubicin-induced cardiotoxicity in rats of various ages. Wistar male rats ( n  = 72) were assigned to three groups (young, adult, and elderly) with three subgroups for each age: doxorubicin (DG, n  = 8), AET + doxorubicin (AETDG, n  = 8), AET + Saline (AETSG, n  = 8). Following the AET intervention, rats were anesthetized and killed to collect heart tissues in order to determine heat shock protein 70 (HSP70), superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-10 (IL10), and c-reactive protein (CRP). Greater levels of SOD and lower levels of MDA were found in young as compared to elderly rats ( P  
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-017-9411-5