Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance

We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a tripl...

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Bibliographic Details
Published in:British journal of haematology 1998-12, Vol.103 (4), p.1161-1163
Main Authors: Ackermann, Jutta, Meidlinger, Petra, Zojer, Niklas, Gisslinger, Heinz, Ludwig, Heinz, Huber, Heinz, Drach, Johannes
Format: Article
Language:English
Subjects:
Biological and medical sciences
Hematology
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
interphase FISH
Medical sciences
MGUS
p53 gene
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Summary:We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence in situ hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1998.01124.x