Ifosfamide and vinorelbine: an active regimen for patients with relapsed or refractory Hodgkin's disease

Twenty‐six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1–4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G‐CSF support. C...

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Bibliographic Details
Published in:British journal of haematology 1998-11, Vol.103 (2), p.533-535
Main Authors: BONFANTE, V, VIVIANI, S, SANTORO, A, DEVIZZI, L, DI RUSSO, A, ZANINI, M, SONCINI, F, SOTO PARRA, H, VALAGUSSA, P, BONADONNA, G
Format: Article
Language:English
Subjects:
Adult
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Chemotherapy
Female
Hematology
Hodgkin Disease - drug therapy
Hodgkin's disease
Humans
ifosfamide
Ifosfamide - administration & dosage
Male
Medical sciences
Middle Aged
Neutropenia - chemically induced
Pharmacology. Drug treatments
Pilot Projects
Recurrence
recurrent disease
Salvage Therapy
Treatment Outcome
Vinblastine - administration & dosage
Vinblastine - analogs & derivatives
Vinorelbine
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Description
Summary:Twenty‐six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1–4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G‐CSF support. Courses were given at 3‐week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1998.00989.x