Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome‐related secondary acute myeloid leukaemia

Seven adult patients with myelodysplastic syndrome (MDS)‐related secondary acute myeloid leukaemia (AML) were treated with total body irradiation (TBI), cytosine arabinoside (Ara‐C) and cyclophosphamide (CY), followed by unrelated human leucocyte antigen (HLA)‐mismatched cord blood transplantation (...

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Bibliographic Details
Published in:British journal of haematology 2001-09, Vol.114 (4), p.834-836
Main Authors: Ooi, Jun, Iseki, Tohru, Nagayama, Hitomi, Tomonari, Akira, Ito, Kiyoshi, Shirafuji, Naoki, Tojo, Arinobu, Tani, Kenzaburo, Asano, Shigetaka
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antimetabolites, Antineoplastic - therapeutic use
Biological and medical sciences
Bone marrow, stem cells transplantation. Graft versus host reaction
cord blood transplantation
Cytarabine - therapeutic use
Female
Fetal Blood
Granulocyte Colony-Stimulating Factor - therapeutic use
G‐CSF
Hematologic and hematopoietic diseases
Hematology
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic Stem Cell Transplantation - mortality
Humans
Leukemia, Myeloid - complications
Leukemia, Myeloid - mortality
Leukemia, Myeloid - surgery
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
myelodysplastic syndrome
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - mortality
Myelodysplastic Syndromes - surgery
Prospective Studies
secondary leukaemia
Survival Rate
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation, Homologous
Whole-Body Irradiation
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Summary:Seven adult patients with myelodysplastic syndrome (MDS)‐related secondary acute myeloid leukaemia (AML) were treated with total body irradiation (TBI), cytosine arabinoside (Ara‐C) and cyclophosphamide (CY), followed by unrelated human leucocyte antigen (HLA)‐mismatched cord blood transplantation (CBT). Granulocyte colony‐stimulating factor (G‐CSF) was infused continuously from 12 h before until the end of Ara‐C therapy to enhance the antileukaemia effect of Ara‐C. Five patients are alive and free of disease at 7–31 months after transplantation. These preliminary results suggest that adult MDS‐related secondary AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.03049.x