Myelodysplastic syndrome in a patient with adult T‐cell leukaemia

A 53‐year‐old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T‐cell leukaemia (ATL) is described. The latent period of therapy‐related MDS (t‐MDS) from the time of diagnosis of ATL was approximately 35 months. Cytogenetic analysis of the bone marrow cells at the tim...

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Bibliographic Details
Published in:British journal of haematology 1999-09, Vol.106 (3), p.702-705
Main Authors: Kawabata, Hisashi, Utsunomiya, Atae, Hanada, Shuichi, Makino, Torahiko, Takatsuka, Yoshifusa, Takeuchi, Shogo, Suzuki, Shinsuke, Suzumiya, Junji, Ohshima, Kouichi, Horiike, Shigeo
Format: Article
Language:English
Subjects:
Adolescent
Adult
adult T‐cell leukaemia
Antineoplastic Agents - adverse effects
Biological and medical sciences
Blotting, Southern
chromosome abnormality
DNA, Viral - isolation & purification
Drug toxicity and drugs side effects treatment
Fatal Outcome
Female
Hematology
Humans
Karyotyping
Leukemia-Lymphoma, Adult T-Cell - complications
Leukemia-Lymphoma, Adult T-Cell - drug therapy
Male
Medical sciences
Middle Aged
Myelodysplastic Syndromes - chemically induced
Pharmacology. Drug treatments
therapy‐related myelodysplastic syndrome
Toxicity: blood
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Summary:A 53‐year‐old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T‐cell leukaemia (ATL) is described. The latent period of therapy‐related MDS (t‐MDS) from the time of diagnosis of ATL was approximately 35 months. Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t‐MDS revealed a clonal abnormality; 46,XX,add(7)(p13), der(17)t(3;17)(p11;p13). Although monoclonal integration of human T lymphotropic virus type I (HTLV‐I) proviral DNA was detected in the peripheral blood lymphocytes at ATL diagnosis, bone marrow cells at t‐MDS diagnosis did not show monoclonal integration of HTLV‐I. To our knowledge, this is the first report of t‐MDS associated with ATL.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1999.01610.x