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Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A
The epigenetic changes induced by environmental contaminants play important roles in the inheritance of male reproductive dysfunction. The present study investigated DNA methylation changes and some oxidative stress biomarkers induced by bisphenol A (BPA) in male offspring. A total number of 48 fema...
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| Published in: | Environmental science and pollution research international 2020-02, Vol.27 (4), p.4513-4519 |
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| creator | El Henafy, Hanan M. A. Ibrahim, Marwa A. Abd El Aziz, Samy A. Gouda, Eman M. |
| description | The epigenetic changes induced by environmental contaminants play important roles in the inheritance of male reproductive dysfunction. The present study investigated DNA methylation changes and some oxidative stress biomarkers induced by bisphenol A (BPA) in male offspring. A total number of 48 female albino rats were administered orally with 50 μg/kg of BPA/day during gestation and/or lactation periods. At postnatal day 60, the samples were collected from the male pups to assess the serum testosterone, malondialdehyde (MDA) level,
superoxide dismutase
(SOD), glutathione S-transferase, and glutathione peroxidase (GSH-Px) activities in testicular tissue. DNA methylation in both DNA (cytosine-5)-methyltransferase 3A and estrogen receptor alpha genes was detected by methylation-specific PCR. BPA exposure resulted in significant decrease in the anogenital distance, testis and epididymis weights, serum testosterone level, SOD, GST, and GSH-Px levels with significant increase in weaning body weight and the MDA level. Additionally, BPA caused marked hypermethylation within Dnmt3A and ER- ∝ genes promoter regions in the testis of rat male pups.
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| doi_str_mv | 10.1007/s11356-019-06553-5 |
| format | article |
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superoxide dismutase
(SOD), glutathione S-transferase, and glutathione peroxidase (GSH-Px) activities in testicular tissue. DNA methylation in both DNA (cytosine-5)-methyltransferase 3A and estrogen receptor alpha genes was detected by methylation-specific PCR. BPA exposure resulted in significant decrease in the anogenital distance, testis and epididymis weights, serum testosterone level, SOD, GST, and GSH-Px levels with significant increase in weaning body weight and the MDA level. Additionally, BPA caused marked hypermethylation within Dnmt3A and ER- ∝ genes promoter regions in the testis of rat male pups.
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superoxide dismutase
(SOD), glutathione S-transferase, and glutathione peroxidase (GSH-Px) activities in testicular tissue. DNA methylation in both DNA (cytosine-5)-methyltransferase 3A and estrogen receptor alpha genes was detected by methylation-specific PCR. BPA exposure resulted in significant decrease in the anogenital distance, testis and epididymis weights, serum testosterone level, SOD, GST, and GSH-Px levels with significant increase in weaning body weight and the MDA level. Additionally, BPA caused marked hypermethylation within Dnmt3A and ER- ∝ genes promoter regions in the testis of rat male pups.
Graphical abstract</description><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Benzhydryl Compounds - adverse effects</subject><subject>Benzhydryl Compounds - chemistry</subject><subject>Biodegradable materials</subject><subject>Biodegradation</subject><subject>Bioreactors</subject><subject>Bisphenol A</subject><subject>Body weight</subject><subject>Composting</subject><subject>Contaminants</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Epigenetics</subject><subject>Estrogens</subject><subject>Female</subject><subject>Male</subject><subject>Management systems</subject><subject>Mechanical properties</subject><subject>Moisture content</subject><subject>Natural & organic foods</subject><subject>Offspring</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>pH effects</subject><subject>Phenols - adverse effects</subject><subject>Phenols - chemistry</subject><subject>Plastics</subject><subject>Polyethylene</subject><subject>Polyethylenes</subject><subject>Polymers</subject><subject>Pregnancy</subject><subject>Process parameters</subject><subject>Rats</subject><subject>Short Research and Discussion Article</subject><subject>Sugar</subject><subject>Testis</subject><subject>Ultraviolet radiation</subject><subject>Waste management</subject><subject>Waste management industry</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Yeast</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp1kE1OwzAQRi0EoqVwARbIEuuAJ7aTeFmVX6miC2Bt2YlLU9Ik2E7VbjkJZ-FkmLYgNqwsffPmefQhdArkAghJLx0A5UlEQEQk4ZxGfA_1IQEWpUyIfdQngrEIKGM9dOTcnJCYiDg9RD0KaUp5zProfbIqC-XLpfn8ePTWOIdVXeCrhyFeGD9bV2HW1Lis8UJVBlvlcdu1Dre2WTavpsB6jf3MYG9V7dpK5ab2qto4NlFI_EYRQrNqG9fZADdYl66dmbqp8PAYHUxV5czJ7h2g55vrp9FdNJ7c3o-G4yhnEPuIkSKfFrHQwDmAynnKKOR0SkkiYsE5y5Si1GQ64ZTlhisqskxpTRKW65RpOkDnW2-4_a0zzst509lwmJMgsiQmGeEQqHhL5bZxzpqpbG25UHYtgcjv2uW2dhlql5vaJQ9LZzt1pxem-F356TkAdAu4MKpfjP3z9__aL5jdj94</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>El Henafy, Hanan M. 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A.</au><au>Ibrahim, Marwa A.</au><au>Abd El Aziz, Samy A.</au><au>Gouda, Eman M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>27</volume><issue>4</issue><spage>4513</spage><epage>4519</epage><pages>4513-4519</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>The epigenetic changes induced by environmental contaminants play important roles in the inheritance of male reproductive dysfunction. The present study investigated DNA methylation changes and some oxidative stress biomarkers induced by bisphenol A (BPA) in male offspring. A total number of 48 female albino rats were administered orally with 50 μg/kg of BPA/day during gestation and/or lactation periods. At postnatal day 60, the samples were collected from the male pups to assess the serum testosterone, malondialdehyde (MDA) level,
superoxide dismutase
(SOD), glutathione S-transferase, and glutathione peroxidase (GSH-Px) activities in testicular tissue. DNA methylation in both DNA (cytosine-5)-methyltransferase 3A and estrogen receptor alpha genes was detected by methylation-specific PCR. BPA exposure resulted in significant decrease in the anogenital distance, testis and epididymis weights, serum testosterone level, SOD, GST, and GSH-Px levels with significant increase in weaning body weight and the MDA level. Additionally, BPA caused marked hypermethylation within Dnmt3A and ER- ∝ genes promoter regions in the testis of rat male pups.
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| ispartof | Environmental science and pollution research international, 2020-02, Vol.27 (4), p.4513-4519 |
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| subjects | Animals Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Benzhydryl Compounds - adverse effects Benzhydryl Compounds - chemistry Biodegradable materials Biodegradation Bioreactors Bisphenol A Body weight Composting Contaminants Deoxyribonucleic acid DNA DNA Methylation Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Epigenetics Estrogens Female Male Management systems Mechanical properties Moisture content Natural & organic foods Offspring Oxidation Oxidative Stress pH effects Phenols - adverse effects Phenols - chemistry Plastics Polyethylene Polyethylenes Polymers Pregnancy Process parameters Rats Short Research and Discussion Article Sugar Testis Ultraviolet radiation Waste management Waste management industry Waste Water Technology Water Management Water Pollution Control Yeast |
| title | Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A |
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