Spontaneous regression of congenital leukaemia with an 8;16 translocation

Congenital leukaemia (CL) is a rare disorder that presents with extramedullary infiltrates and a myeloid phenotype. CL can progress rapidly without adequate treatment, but, paradoxically, may also remit spontaneously. Because of the significant toxicity involved in delivering chemotherapy to newborn...

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Bibliographic Details
Published in:British journal of haematology 2000-11, Vol.111 (2), p.641-643
Main Authors: WEINTRAUB, Michael, KAPLINSKY, Chaim, AMARIGLIO, Ninette, ROSNER, Esther, BROK-SIMONI, Frieda, RECHAVI, Gideon
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 8
Cytogenetic Analysis
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Infant, Newborn
Leukemia, Myeloid - congenital
Leukemia, Myeloid - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Remission, Spontaneous
Translocation, Genetic
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Summary:Congenital leukaemia (CL) is a rare disorder that presents with extramedullary infiltrates and a myeloid phenotype. CL can progress rapidly without adequate treatment, but, paradoxically, may also remit spontaneously. Because of the significant toxicity involved in delivering chemotherapy to newborns, it is important to identify those newborns who may not require treatment. We describe an infant who presented at 1 week of age with congenital myeloid leukaemia. Cytogenetic analysis revealed a t(8;16)(q11;p13) translocation. The infant's leukaemia underwent a spontaneous regression. This case further confirms the possibility of spontaneous remission in congenital leukaemia. Moreover, it suggests that the presence of a clonal cytogenetic aberration does not preclude the possibility of a spontaneous regression in CL.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.02356.x