FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance

The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selec...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2002-06, Vol.117 (3), p.626-628
Main Authors: Rasmussen, Thomas, Hudlebusch, Heidi Rye, Knudsen, Lene Meldgaard, Johnsen, Hans Erik
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - genetics
Carrier Proteins
Female
FGFR3
Fibroblast Growth Factors - genetics
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Hematology
High Mobility Group Proteins - genetics
Histone-Lysine N-Methyltransferase
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Male
Medical sciences
MMSET
multiple myeloma
Multiple Myeloma - genetics
Neoplasm Proteins - genetics
Prognosis
prognostic factor
Protein-Tyrosine Kinases
real‐time RT–PCR
Receptor, Fibroblast Growth Factor, Type 3
Receptors, Fibroblast Growth Factor - genetics
Repressor Proteins
RNA, Messenger - genetics
RNA, Neoplasm - genetics
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selected BM samples were screened for elevated MMSET mRNA levels. 14·5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. Follow‐up of 76 MM patients showed no significant difference between FGFR3 dysfunction and survival (P = 0·3) or correlation with known prognostic factors. Further, no linear relation was observed between FGFR3 and MMSET levels.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2002.03429.x