Targeted pretransplant host lymphocyte depletion prior to T‐cell depleted reduced‐intensity allogeneic stem cell transplantation

Summary Mixed chimaerism and graft rejection are higher after reduced‐intensity allogeneic stem cell transplantation (RIST) with T‐cell depleted (TCD) allografts. As host immune status before RIST affects engraftment, we hypothesized that targeted depletion of host lymphocytes prior to RIST would ab...

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Bibliographic Details
Published in:British journal of haematology 2004-09, Vol.126 (6), p.837-843
Main Authors: Bishop, Michael R., Steinberg, Seth M., Gress, Ronald E., Hardy, Nancy M., Marchigiani, Donna, Kasten‐Sportes, Claude, Dean, Robert, Pavletic, Steven Z., Gea‐Banacloche, Juan, Castro, Kathleen, Hakim, Fran, Krumlauf, Michael, Read, Elizabeth J., Carter, Charles, Leitman, Susan F., Fowler, Daniel H.
Format: Article
Language:English
Subjects:
Adult
allogeneic
Antigens, CD34 - analysis
Biological and medical sciences
Breast Neoplasms - therapy
CD4 Lymphocyte Count
Female
graft rejection
Graft Rejection - prevention & control
Graft Survival
Graft vs Host Disease - prevention & control
Hematologic and hematopoietic diseases
Hematology
Hematopoiesis
Hematopoietic Stem Cell Transplantation - methods
Humans
Lymphocyte Depletion - methods
Lymphocyte Transfusion
Medical sciences
Middle Aged
reduced‐intensity
T-Lymphocytes - immunology
Transplantation Chimera
Transplantation Conditioning - methods
T‐cell depletion
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Summary:Summary Mixed chimaerism and graft rejection are higher after reduced‐intensity allogeneic stem cell transplantation (RIST) with T‐cell depleted (TCD) allografts. As host immune status before RIST affects engraftment, we hypothesized that targeted depletion of host lymphocytes prior to RIST would abrogate graft rejection and promote donor chimaerism. Lymphocyte‐depleting chemotherapy was administered at conventional doses to subjects prior to RIST with the intent of decreasing CD4+ counts to
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2004.05133.x