An efficient and facile synthesis of D-cycloserine substantially free from potential impurities

An efficient and facile synthesis of D-cycloserine has been developed from D-serine with 61% overall yield employing protectiondeprotection strategy. Different parameters affecting the impurities content and yield of D-cycloserine have been studied. Mild reaction conditions provided the product with...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2017-11, Vol.53 (11), p.1248-1253
Main Authors: Awasthi, Arun Kumar, Kumar, Brijesh, Aga, Mushtaq A, Tripathi, Punit, Reddy, Cirandur Suresh, Kumar, Pramod
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Impurities
Organic Chemistry
Pharmacy
Synthesis
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Summary:An efficient and facile synthesis of D-cycloserine has been developed from D-serine with 61% overall yield employing protectiondeprotection strategy. Different parameters affecting the impurities content and yield of D-cycloserine have been studied. Mild reaction conditions provided the product with remarkable purity (>99%) and high stability.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-018-2197-y