Leiomyosarcoma of the great saphenous vein (vena saphena magna) with granular cell change: Report of a superficial neoplasm

The great saphenous vein (GSV) corresponds to the main superficial large‐caliber vessel affected by leiomyosarcoma (LMS). Given its superficial location and because signs of vascular origin may not be clinically apparent, LMS of the GSV may be misinterpreted clinically as superficial nonvascular sof...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2018-02, Vol.45 (2), p.141-145
Main Authors: Macarenco, Ricardo S., Filippi, Renee Z., D’Almeida Costa, Felipe, Jesus‐Garcia, Reynaldo
Format: Article
Language:English
Subjects:
Biopsy
Case reports
granular cell change
great saphenous vein leiomyosarcoma
large‐caliber vessel leiomyosarcoma
Skin
superficial leiomyosarcoma sarcoma
Varicose veins
vascular leiomyosarcoma
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Summary:The great saphenous vein (GSV) corresponds to the main superficial large‐caliber vessel affected by leiomyosarcoma (LMS). Given its superficial location and because signs of vascular origin may not be clinically apparent, LMS of the GSV may be misinterpreted clinically as superficial nonvascular soft tissue mass. Herein, we report a case on the distal portion of the right GSV of a 57‐year‐old man. The histopathological recognition of a large‐caliber vein‐associated LMS (with granular cell change) in an incisional biopsy specimen was crucial to guide radiological evaluation and confirmation of a superficial vascular LMS before surgical treatment. Recognizing this entity in small biopsies is important as its surgical treatment and prognosis differ substantially from nonvascular superficial (ie, subcutaneous and dermal) LMSs. In addition, because vascular LMSs can involve long vessel segments, underestimation of extent of disease is a risk. To the best of our knowledge, granular cell change has not been documented in LMS of the GSV.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13062