Pleomorphic mastocytoma in an adult

Cutaneous mastocytoma (CM) is a localized variant of mastocytosis, characterized by an over‐accumulation of mast cells in the skin, without extra‐cutaneous organ involvement. It is defined as the presence of up to 3 isolated mast‐cell skin lesions and commonly develops in newborns and children. We r...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2018-02, Vol.45 (2), p.176-179
Main Authors: Exposito‐Serrano, Vicente, Agut‐Busquet, Eugenia, Leal Canosa, Lorena, Herrerías Moreno, Jose, Saez, Amparo, Luelmo, Jesús
Format: Article
Language:English
Subjects:
adult mastocytoma
Biopsy
Bone marrow
CD25 antigen
Children
mast cell with bilobed or multilobed nuclei
Mast cells
Mastocytoma
Mastocytosis
Neonates
Nuclei
pleomorphic mastocytoma
Pleomorphism
Skin diseases
Tryptase
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Summary:Cutaneous mastocytoma (CM) is a localized variant of mastocytosis, characterized by an over‐accumulation of mast cells in the skin, without extra‐cutaneous organ involvement. It is defined as the presence of up to 3 isolated mast‐cell skin lesions and commonly develops in newborns and children. We report the case of a 35‐year‐old healthy Caucasian woman presenting with a 4‐year history of a pruritic brown plaque on her left breast. Hematoxylin‐eosin staining showed a dense dermal infiltrate of atypical mast cells extending to the subcutis. The cells presented a marked nuclear pleomorphism with bilobed and multilobed nuclei. Immunohistochemical studies revealed strongly expressed KIT (CD117) and CD25 proteins. Serum tryptase levels and bone marrow biopsy were normal. The diagnosis was a solitary cutaneous pleomorphic mastocytoma. This case can be added to 17 other cases of adult mastocytoma documented in the literature, although, unlike other reported cases, and as far as we are aware, this is the first case of pleomorphic mastocytoma in an adult.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13080