The Effect of Neovascularization on Human Retinal Pigment Epithelium after Hyperbaric Oxygen Therapy

• Published in: Health science journal 2017, Vol.11 (6), p.1-5
• Main Authors: Chao, Chen, Chao, Jian Kang
• Format: Article
• Language: English
• Subjects: Atmospheric pressure; Kinases; Oxygen therapy; Retina; Tumor necrosis factor-TNF
• ISSN: 1791-809X; 1791-809X
• DOI: 10.21767/1791-809X.1000535

Keywords: Hyperbaric oxygen; Human retinal pigment epithelial cells; Pigmented epithelium derived factor; Tumor necrosis factor alpha; Neovascularization Introduction Oxygen is a vital element in all metazoan life forms, it is essential for utilization of metabolic processes, such as energy production, intracellular signaling and regulation of gene expressions [1]. The study showed that senescent eye may be particularly prone to oxidative damage as exemplified by conditions such as macular degeneration and cataract. Because of its high consumption of oxygen, the retina is particularly susceptible to oxidative stress, which plays a major role in retinopathy [3]. When TNF-a binds to TNFR1 (tumor necrosis factor receptor 1) in the retina it leads to the dissociation of inhibitory protein SODD (silencer of death domains), which enables the adaption protein TRADD (Tumor necrosis factor receptor type 1-associated death domain protein) and initiates the activation of NF-kB pathway and mitogen-activated protein kinase (MAPK) pathway. [...]prolonged HBO treatment can cause failure in the antioxidant defense system, leading to oxidative damages to ocular structures and cause the development of myopia, nuclear cataracts and keratoconus [12-14].