Effect of different preparations of hormone therapy on sexual dysfunction in naturally postmenopausal women

Objective To compare the effect of different formulations of continuous combined hormone therapy on sexual performance in naturally postmenopausal women. Material and methods A total of 158 postmenopausal women were enrolled and prospectively randomized to the single-blind study. Fifty-four women re...

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Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society 2006-12, Vol.9 (6), p.464-472
Main Authors: Osmana ao lu, M. A., Atasaral, T., Baltac, D., Bozkaya, H.
Format: Article
Language:English
Subjects:
Arousal
Coitus - physiology
Coitus - psychology
Estradiol - therapeutic use
Estrogen Receptor Modulators - therapeutic use
Estrogen Replacement Therapy
Female
Hormone Antagonists - therapeutic use
Hormone replacement therapy
HORMONE THERAPY
Humans
Informed consent
Libido
Menopause
Middle Aged
Nandrolone - analogs & derivatives
Nandrolone - therapeutic use
Norpregnenes - therapeutic use
Patient Satisfaction
POSTMENOPAUSAL WOMEN
Postmenopause
Prospective Studies
Quality of Life
SEXUAL DYSFUNCTION
Sexual Dysfunction, Physiological - drug therapy
Sexual Dysfunction, Physiological - psychology
Single-Blind Method
Treatment Outcome
Women
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Summary:Objective To compare the effect of different formulations of continuous combined hormone therapy on sexual performance in naturally postmenopausal women. Material and methods A total of 158 postmenopausal women were enrolled and prospectively randomized to the single-blind study. Fifty-four women received tibolone 2.5 mg, 53 received 2 mg estradiol and 2 mg dienogest (E2 dienogest), and 51 did not receive any menopausal therapy. The patients were monitored after 6 months. Attitudes of sexuality were evaluated by using the Rosen's female sexual function index. Results Compared with E2 dienogest and the control group, tibolone treatment was associated with more improvement of sexual performance, including sexual desire, sexual arousal and satisfaction. Both of the hormone therapies decreased frequencies of vaginal dryness and painful intercourse. Conclusions Tibolone has more positive effects on the sexual dysfunction of postmenopausal women and may be an alternative to the E2 dienogest preparation in postmenopausal women with sexual dysfunction.
ISSN:1369-7137
1473-0804
DOI:10.1080/13697130600997775