HLA-DRB3 0101 is associated with Graves' disease in Jamaicans

OBJECTIVES Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104...

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Published in:Clinical endocrinology (Oxford) 2001-12, Vol.55 (6), p.805-808
Main Authors: Smikle, Monica Fisher, Pascoe, Rosemarie Wright, Barton, Everard, Morgan, Owen, Christian, Nicole, Dowe, Gwendolyn, Roye-Green, Karen, Bailey, Valerie, James, Owen
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Language:English
Subjects:
Biological and medical sciences
Endocrinopathies
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thyroid. Thyroid axis (diseases)
Tropical medicine
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cited_by cdi_FETCH-LOGICAL-c3214-6831256584631d9c2522aba94c4d1b17ee1088e48cfdd8b552d1e7450b8eb8de3
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container_issue 6
container_start_page 805
container_title Clinical endocrinology (Oxford)
container_volume 55
creator Smikle, Monica Fisher
Pascoe, Rosemarie Wright
Barton, Everard
Morgan, Owen
Christian, Nicole
Dowe, Gwendolyn
Roye-Green, Karen
Bailey, Valerie
James, Owen
description OBJECTIVES Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104 controls. DESIGN Oligotyping for HLA‐DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR‐SSOP) technique. RESULTS The frequency of HLA‐DRB3 *0101 was increased significantly in the patients compared to controls (38·7% vs. 19·2%; RR = 2·72; Pc 
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This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104 controls. DESIGN Oligotyping for HLA‐DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR‐SSOP) technique. RESULTS The frequency of HLA‐DRB3 *0101 was increased significantly in the patients compared to controls (38·7% vs. 19·2%; RR = 2·72; Pc &lt; 0·015). The protective alleles for Graves' disease were DRB1 *0901 (0·9% vs. 20·2%; RR = 0·04; Pc &lt; 0·001), DRB1*1001 (0·0% vs. 11%; RR = 0·0%; Pc &lt; 0·01) and DRB4 *0101 (0·0% vs. 12·5%; RR = 0·0; Pc &lt; 0·05). A high female to male ratio of Graves' disease, 25 : 1, was observed. Other associated autoimmune diseases were rare and no significant HLA class II associations were found with clinical markers of disease. CONCLUSIONS Jamaican patients with Graves' disease share the DRB3 *0101 susceptible allele and the DRB4 *01 protective allele but not the susceptible haplotype DRB1 *0301, DRB3 *0101, DQA1 *0501 with Caucasians.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1046/j.1365-2265.2001.01414.x</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Endocrinopathies ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Thyroid. Thyroid axis (diseases) ; Tropical medicine</subject><ispartof>Clinical endocrinology (Oxford), 2001-12, Vol.55 (6), p.805-808</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104 controls. DESIGN Oligotyping for HLA‐DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR‐SSOP) technique. RESULTS The frequency of HLA‐DRB3 *0101 was increased significantly in the patients compared to controls (38·7% vs. 19·2%; RR = 2·72; Pc &lt; 0·015). The protective alleles for Graves' disease were DRB1 *0901 (0·9% vs. 20·2%; RR = 0·04; Pc &lt; 0·001), DRB1*1001 (0·0% vs. 11%; RR = 0·0%; Pc &lt; 0·01) and DRB4 *0101 (0·0% vs. 12·5%; RR = 0·0; Pc &lt; 0·05). A high female to male ratio of Graves' disease, 25 : 1, was observed. Other associated autoimmune diseases were rare and no significant HLA class II associations were found with clinical markers of disease. CONCLUSIONS Jamaican patients with Graves' disease share the DRB3 *0101 susceptible allele and the DRB4 *01 protective allele but not the susceptible haplotype DRB1 *0301, DRB3 *0101, DQA1 *0501 with Caucasians.</description><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Tropical medicine</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqNkE1LAzEQhoMoWD_-QxDE064z-dr04EGrtkr9RBF6Cdlsiqm1rUnV9t-7a0WvnmZg3ucdeAihCDmCUIejHLmSGWNK5gwAc0CBIl-skdbvYZ20gANkoJTYJFspjQBAaiha5KjXP85O7084BQSkIVGb0tQFO_cV_QzzZ9qN9sOnA1qF5G3yNEzopX21wdlJ2iEbQztOfvdnbpPH87OHTi_r33QvOsf9zHGGIlOaI5NKaqE4Vm3HJGO2tG3hRIUlFt4jaO2FdsOq0qWUrEJfCAml9qWuPN8me6veWZy-vfs0N6Ppe5zULw22dSE106oO6VXIxWlK0Q_NLIZXG5cGwTSuzMg0SkyjxDSuzLcrs6jR_Z9-m5wdD6OduJD-eIGq0EzWuaNV7jOM_fLf_aZzdt1sNZ-t-JDmfvHL2_hiVMELaZ6uu0Zj7-6KDQbmln8BO9aHsA</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Smikle, Monica Fisher</creator><creator>Pascoe, Rosemarie Wright</creator><creator>Barton, Everard</creator><creator>Morgan, Owen</creator><creator>Christian, Nicole</creator><creator>Dowe, Gwendolyn</creator><creator>Roye-Green, Karen</creator><creator>Bailey, Valerie</creator><creator>James, Owen</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>200112</creationdate><title>HLA-DRB3 0101 is associated with Graves' disease in Jamaicans</title><author>Smikle, Monica Fisher ; Pascoe, Rosemarie Wright ; Barton, Everard ; Morgan, Owen ; Christian, Nicole ; Dowe, Gwendolyn ; Roye-Green, Karen ; Bailey, Valerie ; James, Owen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3214-6831256584631d9c2522aba94c4d1b17ee1088e48cfdd8b552d1e7450b8eb8de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smikle, Monica Fisher</creatorcontrib><creatorcontrib>Pascoe, Rosemarie Wright</creatorcontrib><creatorcontrib>Barton, Everard</creatorcontrib><creatorcontrib>Morgan, Owen</creatorcontrib><creatorcontrib>Christian, Nicole</creatorcontrib><creatorcontrib>Dowe, Gwendolyn</creatorcontrib><creatorcontrib>Roye-Green, Karen</creatorcontrib><creatorcontrib>Bailey, Valerie</creatorcontrib><creatorcontrib>James, Owen</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smikle, Monica Fisher</au><au>Pascoe, Rosemarie Wright</au><au>Barton, Everard</au><au>Morgan, Owen</au><au>Christian, Nicole</au><au>Dowe, Gwendolyn</au><au>Roye-Green, Karen</au><au>Bailey, Valerie</au><au>James, Owen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DRB3 0101 is associated with Graves' disease in Jamaicans</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><date>2001-12</date><risdate>2001</risdate><volume>55</volume><issue>6</issue><spage>805</spage><epage>808</epage><pages>805-808</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>OBJECTIVES Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This study was designed to examine the HLA class II associations with Graves' disease in Jamaicans. PATIENTS One hundred and six Jamaicans with Graves' disease and 104 controls. DESIGN Oligotyping for HLA‐DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR‐SSOP) technique. RESULTS The frequency of HLA‐DRB3 *0101 was increased significantly in the patients compared to controls (38·7% vs. 19·2%; RR = 2·72; Pc &lt; 0·015). The protective alleles for Graves' disease were DRB1 *0901 (0·9% vs. 20·2%; RR = 0·04; Pc &lt; 0·001), DRB1*1001 (0·0% vs. 11%; RR = 0·0%; Pc &lt; 0·01) and DRB4 *0101 (0·0% vs. 12·5%; RR = 0·0; Pc &lt; 0·05). A high female to male ratio of Graves' disease, 25 : 1, was observed. Other associated autoimmune diseases were rare and no significant HLA class II associations were found with clinical markers of disease. CONCLUSIONS Jamaican patients with Graves' disease share the DRB3 *0101 susceptible allele and the DRB4 *01 protective allele but not the susceptible haplotype DRB1 *0301, DRB3 *0101, DQA1 *0501 with Caucasians.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><doi>10.1046/j.1365-2265.2001.01414.x</doi><tpages>4</tpages></addata></record>
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subjects Biological and medical sciences
Endocrinopathies
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thyroid. Thyroid axis (diseases)
Tropical medicine
title HLA-DRB3 0101 is associated with Graves' disease in Jamaicans
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