Hormone therapy for younger postmenopausal women: how can we make sense out of the evidence?

The Women's Health Initiative (WHI) trials have provided us with valuable information on the effect of hormone therapy (HT) in older postmenopausal women. These results have been generalized to women of all ages, despite the fact that the trials were not powered to evaluate the effect of HT in...

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Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society 2005-12, Vol.8 (4), p.307-310
Main Author: Salpeter, Shelley
Format: Article
Language:English
Subjects:
Age Factors
Aged
Cardiovascular disease
Coronary Disease - prevention & control
Estrogen Replacement Therapy - adverse effects
Estrogens - therapeutic use
Female
Hormone replacement therapy
Humans
Medroxyprogesterone - therapeutic use
Menopause
Middle Aged
Mortality
Postmenopause - drug effects
Randomized Controlled Trials as Topic
Risk Assessment
Side effects
Women
Women's Health
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Summary:The Women's Health Initiative (WHI) trials have provided us with valuable information on the effect of hormone therapy (HT) in older postmenopausal women. These results have been generalized to women of all ages, despite the fact that the trials were not powered to evaluate the effect of HT in younger women who initiate treatment shortly after menopause. Pooled data from the WHI and other randomized trials now reveal that HT in younger women is associated with a reduction in coronary heart disease events and total mortality, a benefit that is not seen in older women.
ISSN:1369-7137
1473-0804
DOI:10.1080/13697130500345505