Cognitive dysfunction in patients with pituitary tumour who have been treated with transfrontal or transsphenoidal surgery or medication

• Published in: Clinical endocrinology (Oxford) 1998-09, Vol.49 (3), p.391-396
• Main Authors: PEACE, K. A, ORME, S. M, PADAYATTY, S. J, GODFREY, H. P. D, BELCHETZ, P. E
• Format: Article
• Language: English
• Subjects: Adult; Attention; Biological and medical sciences; Case-Control Studies; Cognition Disorders - etiology; Humans; Medical sciences; Memory Disorders - etiology; Neuropsychological Tests; Neurosurgery; Pituitary Irradiation - adverse effects; Pituitary Neoplasms - psychology; Pituitary Neoplasms - surgery; Pituitary Neoplasms - therapy; Postoperative Period; Skull, brain, vascular surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1046/j.1365-2265.1998.00543.x

OBJECTIVE This study was carried out to examine the neuropsychological status of patients treated for pituitary tumour by transfrontal surgery, transsphenoidal surgery or medical treatment only, with or without radiotherapy. DESIGN AND MEASUREMENTS Three groups of 23 patients who had been treated for pituitary tumour were compared with 23 healthy controls on a range of neuropsychological measures. The surgical patients were also subdivided into two groups and compared. The neuropsychological measures were standardized psychological tests designed to assess aspects of attention, memory and executive function. PATIENTS The patients were those who had been treated with transfrontal surgery (n = 23), transsphenoidal surgery (n = 23) and medication only (n = 23). The groups did not differ with respect to age, education or premorbid ability level as assessed by the National Adult Reading Test. All participants were free of known sources of cognitive impairment other than pituitary tumour. RESULTS Comparison of the four groups revealed that nearly half of the transfrontal, one‐third of the transsphenoidal and one‐quarter of the non‐surgical group had three or more neuropsychological tests scores below the 10th percentile compared to less than 5% of the controls. Impairments in memory and executive function were found in both surgical groups. The non‐surgical patients appeared to have problems only on tasks requiring high levels of cognitive processing. Differences were found between the two surgical groups with respect to the severity of the cognitive impairment, the transfrontal patients having more severe impairment than the transsphenoidal. No significant negative effects on cognitive functioning were associated with radiotherapy; however, transfrontal surgery patients who had not been treated with radiotherapy were found to be more impaired than other patients. This was thought to be related to radical surgery. CONCLUSIONS Many patients with treated pituitary tumour suffer significant cognitive impairment. The severity and nature of impairment differs between treatment groups, although the cause of this could not be addressed by this study. Recommendations are made for future research and clinical practice.