Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective study

Summary Objective  To investigate the risk of hypothyroidism after radioiodine (131I) treatment for hyperfunctioning thyroid nodules. Design  Retrospective analysis of patients treated with 131I for hyperfunctioning thyroid nodules and followed up for a maximum of 20 years. Patients  A total of 346...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2005-03, Vol.62 (3), p.331-335
Main Authors: Ceccarelli, Claudia, Bencivelli, Walter, Vitti, Paolo, Grasso, Lucia, Pinchera, Aldo
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Antithyroid Agents - adverse effects
Biological and medical sciences
Disease Progression
Endocrinopathies
Epidemiologic Methods
Female
Fundamental and applied biological sciences. Psychology
Humans
Hyperthyroidism - radiotherapy
Hypothyroidism - etiology
Iodine Radioisotopes - adverse effects
Iodine Radioisotopes - therapeutic use
Male
Medical sciences
Methimazole - adverse effects
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Radiation Injuries - etiology
Thyroid Gland - physiology
Thyroid Nodule - radiotherapy
Thyroid. Thyroid axis (diseases)
Thyrotropin - blood
Treatment Outcome
Vertebrates: endocrinology
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Summary:Summary Objective  To investigate the risk of hypothyroidism after radioiodine (131I) treatment for hyperfunctioning thyroid nodules. Design  Retrospective analysis of patients treated with 131I for hyperfunctioning thyroid nodules and followed up for a maximum of 20 years. Patients  A total of 346 patients treated with 131I in the years 1975–95, for a single hyperfunctioning nodule. Measurements  Hypothyroidism was defined as TSH levels > 3·7 mU/l. Kaplan–Meier survival analysis was used to analyse permanence of euthyroidism after 131I. A stepwise Cox proportional hazard model was used to identify factors influencing the progression to hypothyroidism. Results  The cumulative incidence of hypothyroidism was 7·6% at 1 year, 28% at 5 years, 46% at 10 years and 60% at 20 years. Age (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2005.02218.x