Analysis of the association between IL-23R rs11209026 polymorphism in rheumatoid arthritis and systemic lupus erythematosus in an Iranian population

Introduction: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are two autoimmune inflammatory diseases with possible genetic links. In this study, the polymorphism R381Q IL-23R in patients with RA, SLE, and healthy controls and its relation to genotype was investigated. Materials an...

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Bibliographic Details
Published in:Annals of tropical medicine and public health 2017-11, Vol.10 (6), p.1656-1660
Main Authors: Motlagh, Shadi, Ashkezari, Mahmood, Ahmadi, Kolsum, Soleymani, Azam, Kiani, Ali
Format: Article
Language:English
Subjects:
Analysis
Autoimmune diseases
Cytokines
Data analysis
Deoxyribonucleic acid
DNA
Genes
Genetic aspects
Genotypes
Inflammation
Inflammatory bowel disease
Inflammatory diseases
Interleukins
Lupus
Psoriasis
Research centers
Rheumatoid arthritis
Signal transduction
Single nucleotide polymorphisms
Studies
Systemic lupus erythematosus
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Summary:Introduction: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are two autoimmune inflammatory diseases with possible genetic links. In this study, the polymorphism R381Q IL-23R in patients with RA, SLE, and healthy controls and its relation to genotype was investigated. Materials and Methods: In this case-control study of 100 patients with SLE, 100 patients with RA and 112 healthy individuals who were referred to the rheumatology ward of some hospitals in Khorramabad (Lorestan province, west of Iran) were selected. Genomic DNA was extracted from peripheral blood and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism method. Fisher's exact test was used to compare data from genotypes and alleles between all groups. Results: It was found that polymorphism A > G rs11209026 of IL-23R gene in the control group and patients with RA had significant difference (P = 0.046). However in the control group and SLE patients, there was no significant difference (P = 0.51). Conclusion: The results indicate that single nucleotide polymorphism rs11209026 G > A of the IL-23R gene is possibly associated with RA. IL-23 is an important inflammatory cytokine and essential for the differentiation of Th17 cells. Hence studies related to the role of Th17 cells in the pathogenesis of RA would help provide more insights into its regulatory mechanisms.
ISSN:1755-6783
0974-6005
DOI:10.4103/ATMPH.ATMPH_571_17